[THE CONTENT OF BILE ACIDS IN THE SERUM OF PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE].

AIM

Rate content of primary, secondary, tertiary and unconjugated bile acids in the blood of patients with NAFLD.

METHODS

The study involved 74 patients with NAFLD (male--30, female--44) And 51 healthy individuals (male--14, female--37). All patients underwent anthropometry and they had a complete clinical, biochemical and instrumental examination (determination of the amount of fat in the subcutaneous fat layer). Patients with hepatic steatosis were--64 people, with steatohepatitis--10 people. The content of bile acids (primary: cholic, chenodeoxycholic; secondary: lithocholic, deoxycholic and tertiary: ursodeoxycholic) in serum were determined by gas-liquid chromatography, chromatography "Chromos GC-1000" (Russia).

RESULTS

In the blood of healthy individuals and patients with NAFLD are determined unconjugated primary, secondary and tertiary LCD. In healthy individuals there are no gender differences in the content of the LCD. NAFLD patients LCD level higher than that of healthy individuals. There is a significant difference in the concentration of secondary and tertiary LCD in patients with hepatic steatosis and steatohepatitis.

CONCLUSIONS

1. The content of the bile acids in the blood of patients with NAFLD significantly higher than in healthy individuals. 2. When steatohepatitis compared with hepatic steatosis, there are more significant fluctuations in the blood content of the LCD according to gender and type of LCD. So, cholic, chenodeoxycholic and deoxycholic higher than that of men, while, lithocholic and UDCA below. 3. Significant difference in the content of fatty acids in the blood between patients with hepatic steatosis and steatohepatitis exists only in relation to the secondary and tertiary LCD. Thus, when steatohepatitis compared with hepatic steatosis litoheolevaya acid and UDCA more in men and deoxycholic below. Conversely, women and lithocholic UDCA below and above deoxycholic acid.