帕金森病与幽门螺杆菌之间的关联
Association between Parkinson's Disease and Helicobacter Pylori.
作者信息
Çamcı Gülşah, Oğuz Sıdıka
机构信息
Arrhythmias Unit, Research and Application Hospital, Kocaeli University, Kocaeli, Turkey.
Internal Medicine Nursing Department, Nursing Department, Health Sciences Faculty, Marmara University, Üsküdar, Istanbul, Turkey.
出版信息
J Clin Neurol. 2016 Apr;12(2):147-50. doi: 10.3988/jcn.2016.12.2.147. Epub 2016 Feb 26.
Abstract
Helicobacter pylori (HP) is a common infection of the gastrointestinal system that is usually related to peptic ulcers. However, recent studies have revealed relationships between HP and many other diseases. Although the exact mechanism is unknown, HP can prevent the absorption of certain drugs. A high prevalence of HP has been found in patients with Parkinson's disease, and this bacterium causes motor fluctuations by affecting the absorption of levodopa, which is the main drug used to treat Parkinson's disease. Eradicating HP from patients with Parkinson's disease by applying antibiotic treatment will increase the absorption of levodopa and decrease their motor fluctuations.
摘要
幽门螺杆菌（HP）是消化系统的一种常见感染，通常与消化性溃疡有关。然而，最近的研究揭示了HP与许多其他疾病之间的关系。尽管确切机制尚不清楚，但HP可阻止某些药物的吸收。在帕金森病患者中发现HP的高患病率，并且这种细菌通过影响左旋多巴（治疗帕金森病的主要药物）的吸收而导致运动波动。通过应用抗生素治疗根除帕金森病患者体内的HP将增加左旋多巴的吸收并减少其运动波动。
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