解析免疫反应枢纽：MyD88 结构建模。

Dissecting a Hub for Immune Response: Modeling the Structure of MyD88.

机构信息

Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy; Laboratory of Neuroembryology, Fondazione Santa Lucia, 00143 Rome, Italy.

出版信息

Structure. 2016 Mar 1;24(3):349-51. doi: 10.1016/j.str.2016.02.005.

DOI:10.1016/j.str.2016.02.005

PMID:26933969

Abstract

Immune cells sense foreign organisms through the evolutionarily conserved family of Toll-like receptors. Signaling from these receptors relies on oligomerization of adaptor molecules. In this issue of Structure, Vynke et al. (2016) shed light on the dynamical structure of the homo- and hetero-dimerization domain of MyD88, the main adaptor utilized by Toll-like receptors.

摘要

免疫细胞通过进化上保守的 Toll 样受体家族感知外来生物。这些受体的信号依赖于衔接分子的寡聚化。在本期的《结构》杂志中，Vynke 等人（2016）揭示了 Toll 样受体主要衔接分子 MyD88 同源和异源二聚化结构域的动态结构。