Felgner Sebastian, Kocijancic Dino, Frahm Michael, Curtiss Roy, Erhardt Marc, Weiss Siegfried
a Department of Molecular Immunology , Helmholtz Centre for Infection Research , Braunschweig , Germany.
b Department of Infectious Diseases and Pathology , University of Florida , Gainesville , USA.
Gut Microbes. 2016;7(2):171-7. doi: 10.1080/19490976.2016.1155021.
Bacteria-mediated tumor therapy using Salmonella enterica serovar Typhimurium is a therapeutic option with great potential. Numerous studies explored the potential of Salmonella Typhimurium for therapeutic applications, however reconciling safety with vectorial efficacy remains a major issue. Recently we have described a conditionally attenuated Salmonella vector that is based on genetic lipopolysaccharide modification. This vector combines strong attenuation with appropriate anti-tumor properties by targeting various cancerous tissues in vivo. Therefore, it was promoted as an anti-tumor agent. In this addendum, we summarize these findings and demonstrate additional optimization steps that may further improve the therapeutic efficacy of our vector strain.
使用鼠伤寒沙门氏菌进行细菌介导的肿瘤治疗是一种具有巨大潜力的治疗选择。众多研究探索了鼠伤寒沙门氏菌在治疗应用中的潜力,然而,在确保安全性的同时兼顾载体有效性仍是一个主要问题。最近,我们描述了一种基于基因脂多糖修饰的条件性减毒沙门氏菌载体。该载体通过靶向体内各种癌组织,将强大的减毒作用与适当的抗肿瘤特性相结合。因此,它被作为一种抗肿瘤药物进行推广。在本附录中,我们总结了这些发现,并展示了可能进一步提高我们载体菌株治疗效果的其他优化步骤。