黄斑淀粉样变与爱泼斯坦-巴尔病毒

Macular Amyloidosis and Epstein-Barr Virus.

作者信息

Nahidi Yalda, Tayyebi Meibodi Naser, Meshkat Zahra, Nazeri Narges

机构信息

Skin Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9176699199, Iran.

Virology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9176699199, Iran.

出版信息

Dermatol Res Pract. 2016;2016:6089102. doi: 10.1155/2016/6089102. Epub 2016 Feb 14.

DOI:10.1155/2016/6089102

PMID:26981113

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4769766/

Abstract

Background. Amyloidosis is extracellular precipitation of eosinophilic hyaline material of self-origin with special staining features and fibrillar ultrastructure. Macular amyloidosis is limited to the skin, and several factors have been proposed for its pathogenesis. Detection of Epstein-Barr virus (EBV) DNA in this lesion suggests that this virus can play a role in pathogenesis of this disease. Objective. EBV DNA detection was done on 30 skin samples with a diagnosis of macular amyloidosis and 31 healthy skin samples in the margin of removed melanocytic nevi by using PCR. Results. In patients positive for beta-globin gene in PCR, BLLF1 gene of EBV virus was positive in 23 patients (8 patients in case and 15 patients in the control group). There was no significant difference in presence of EBV DNA between macular amyloidosis (3.8%) and control (23.8%) groups (P = 0.08). Conclusion. The findings of this study showed that EBV is not involved in pathogenesis of macular amyloidosis.

摘要

背景。淀粉样变性是自身来源的嗜酸性透明物质在细胞外沉淀，具有特殊的染色特征和纤维状超微结构。斑状淀粉样变性局限于皮肤，其发病机制已提出多种因素。在该病变中检测到爱泼斯坦 - 巴尔病毒（EBV）DNA提示该病毒可能在本病的发病机制中起作用。目的。通过聚合酶链反应（PCR）对30例诊断为斑状淀粉样变性的皮肤样本和31例切除的黑素细胞痣边缘的健康皮肤样本进行EBV DNA检测。结果。在PCR中β-珠蛋白基因阳性的患者中，EBV病毒的BLLF1基因在23例患者中呈阳性（病例组8例，对照组15例）。斑状淀粉样变性组（3.8%）和对照组（23.8%）之间EBV DNA的存在无显著差异（P = 0.08）。结论。本研究结果表明EBV不参与斑状淀粉样变性的发病机制。