口腔白斑和口腔鳞状细胞癌的计算机辅助形态计量分析
Computer aided morphometric analysis of oral leukoplakia and oral squamous cell carcinoma.
作者信息
Gupta K, Gupta J, Miglani R
机构信息
a Department of Oral and Maxillofacial Pathology , Mithila Minority Dental College and Hospital , Darbhanga , Bihar , India.
b Department of Oral Medicine and Radiology , Mithila Minority Dental College and Hospital , Darbhanga , Bihar , India.
出版信息
Biotech Histochem. 2016;91(4):251-4. doi: 10.3109/10520295.2016.1139181. Epub 2016 Mar 16.
We compared the changes in the cells in the basal layer of normal mucosa, oral leukoplakia with dysplasia and different grades of oral squamous cell carcinoma (OSCC) using computer aided image analysis of tissue sections. We investigated three morphometric parameters: nuclear area (NA), cell area (CA) and their ratio (NA:CA). NA and NA:CA ratio showed a statistically significant increase from dysplasia to increasing grades of OSCC. Nuclear size was useful for differentiating normal tissue, potentially malignant leukoplakia and OSCC.
我们使用组织切片的计算机辅助图像分析，比较了正常黏膜基底层、发育异常的口腔白斑和不同分级的口腔鳞状细胞癌（OSCC）中细胞的变化。我们研究了三个形态测量参数：核面积（NA）、细胞面积（CA）及其比值（NA:CA）。从发育异常到OSCC分级增加，NA和NA:CA比值显示出统计学上的显著增加。核大小有助于区分正常组织、潜在恶性白斑和OSCC。
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