泊洛沙姆407基制剂在感染甲板模型中抗真菌疗效的体外评价
In vitro evaluation of the antifungal efficacy of poloxamer 407-based formulations in an infected nail plate model.
作者信息
Täuber Anja, Müller-Goymann Christel C
机构信息
Institut für Pharmazeutische Technologie, Technische Universität Braunschweig, Mendelssohnstraße 1, 38106 Braunschweig, Germany.
Institut für Pharmazeutische Technologie, Technische Universität Braunschweig, Mendelssohnstraße 1, 38106 Braunschweig, Germany.
出版信息
Int J Pharm. 2016 May 30;505(1-2):20-3. doi: 10.1016/j.ijpharm.2016.01.082. Epub 2016 Mar 15.
The in vitro efficacy of poloxamer 407-based formulations with antifungal ciclopirox olamine has been analysed in an infected nail plate model. As artificial nail plates, keratin films made of human hair keratin and slices from bovine hooves have been utilised. Several poloxamer 407-based formulations with 1 % active ingredient indicated complete growth inhibition of the dermatophyte fungus Trichophyton rubrum after 6days of incubation.
在感染的指甲板模型中分析了含抗真菌药环吡酮胺的泊洛沙姆407制剂的体外疗效。作为人造指甲板，使用了由人发角蛋白制成的角蛋白膜和牛蹄切片。几种含1%活性成分的泊洛沙姆407制剂在孵育6天后显示对皮肤癣菌红色毛癣菌有完全的生长抑制作用。
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