Brzozowska A
Rocz Panstw Zakl Hig. 1989;40(4-6):302-12.
In the light of the pertinent literature the sites and mechanisms of interactions of iron, zinc and copper in the human and animal organism are discussed. Both low and high intake of any of them may influence the utilization and metabolism of both remaining ones. E.G. dietary copper deficiency impairs the mobilization of iron reserves from the liver, and its excess inhibits the intestinal absorption of iron and zinc. Iron in excess may antagonize copper and zinc in the intestinal mucosa. Zinc excess has an unfavourable influence on iron balance by reducing the bioavailability of copper, and zinc deficiency reduces the rate of protein synthesis impairing, among others, the transport of these elements with blood. The occurrence of interaction depends on the mutual proportions of components and their sum in the diet. Attention is called to these interrelationships which are of practical importance in human nutrition.
根据相关文献，讨论了铁、锌和铜在人和动物机体中的相互作用部位及机制。其中任何一种元素的摄入量过低或过高，都可能影响另外两种元素的利用和代谢。例如，膳食中铜缺乏会损害肝脏中铁储备的动员，而铜过量则会抑制铁和锌的肠道吸收。过量的铁可能在肠黏膜中拮抗铜和锌。锌过量会通过降低铜的生物利用度对铁平衡产生不利影响，而锌缺乏会降低蛋白质合成速率，尤其会损害这些元素在血液中的运输。相互作用的发生取决于饮食中各成分的相互比例及其总量。人们应关注这些相互关系，它们在人类营养中具有实际重要性。
