Bala K A, Doğan M, Mutluer T, Kaba S, Aslan O, Balahoroğlu R, Çokluk E, Üstyol L, Kocaman S
Department of Pediatrics and Division of Pediatric Endocrinology; Medical School, Yüzüncü Yil University, Van, Turkey.
Eur Rev Med Pharmacol Sci. 2016 Mar;20(5):923-9.
In our study, we aimed to reveal pathophysiologic mechanisms in ASD by comparing plasma amino acid levels between patients and healthy controls while considering vitamin B12 and D levels.
The study included 21 patients aged 2-18 years-old who were followed with a diagnosis autism spectrum disorder (ASD) and 21 age and sex-matched healthy children from our outpatient clinic as control group.
The study included 42 children and adolescents aged 2-18 years-old (19 girls and 23 boys). There were no significant differences in terms of body weight and height between the groups. We found significant differences in levels of ammonium, phosphoethanolamine, histidine, homocysteine, carnosine, methionine, cystathionine, cystine, threonine, 3-methyl histidine and phenylalanine/tyrosine ratio between patient and control groups. Both vitamin B12 and D were significantly lower in the ASD group compared to controls. In the variance analysis with vitamin B12 and D as covariates, significant differences persisted for only phosphoethanolamine (p=0.04), cystathionine (p<0.001), cystine (p=0.006) and threonine (p=0.02).
Further studies are needed on the amino acids that show variations in children with ASD in order to reveal their role in the etiology and therapeutic use in ASD.
在我们的研究中，我们旨在通过比较患者与健康对照者的血浆氨基酸水平，同时考虑维生素B12和D水平，来揭示自闭症谱系障碍（ASD）的病理生理机制。
该研究纳入了21名年龄在2至18岁之间、被诊断为自闭症谱系障碍（ASD）的患者，以及21名来自我们门诊的年龄和性别匹配的健康儿童作为对照组。
该研究纳入了42名年龄在2至18岁之间的儿童和青少年（19名女孩和23名男孩）。两组之间在体重和身高方面没有显著差异。我们发现患者组与对照组在铵、磷酸乙醇胺、组氨酸、同型半胱氨酸、肌肽、蛋氨酸、胱硫醚、胱氨酸、苏氨酸、3 - 甲基组氨酸以及苯丙氨酸/酪氨酸比值的水平上存在显著差异。与对照组相比，ASD组的维生素B12和D水平均显著降低。在以维生素B12和D作为协变量的方差分析中，仅磷酸乙醇胺（p = 0.04）、胱硫醚（p < 0.001）、胱氨酸（p = 0.006）和苏氨酸（p = 0.02）存在显著差异。
需要对在患有ASD的儿童中表现出变化的氨基酸进行进一步研究，以揭示它们在ASD病因学中的作用以及治疗用途。
