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本科及研究生牙科学生中潜伏性结核感染的患病率及相关危险因素:一项回顾性研究。

Prevalence and associated risk factors of latent tuberculosis infection among undergraduate and postgraduate dental students: A retrospective study.

作者信息

Lamberti Monica, Muoio Maria Rosaria, Westermann Claudia, Nienhaus Albert, Arnese Antonio, Ribeiro Sobrinho Antônio Paulino, Di Giuseppe Gabriella, Garzillo Elpidio Maria, Crispino Vincenzo, Coppola Nicola, De Rosa Alfredo

机构信息

a Department of Experimental Medicine , Section of Hygiene, Occupational Medicine and Forensic Medicine, Second University of Naples , Naples , Italy.

b Institute for Health Services Research in Dermatology and Nursing, University Medical Center Hamburg-Eppendorf , Hamburg , Germany.

出版信息

Arch Environ Occup Health. 2017 Mar 4;72(2):99-105. doi: 10.1080/19338244.2016.1167006. Epub 2016 Mar 28.

Abstract

To estimate the prevalence of latent tuberculosis (TB) infection (LTBI) in Italian dental students exposed to the same occupational risks as dental health care personnel and to evaluate potential risk factors, a cross-sectional study was conducted on undergraduate and postgraduate students. After clinical evaluation, students were given a tuberculin skin test; in those found positive, an interferon-γ release assay (IGRA) was conducted. Of the 281 students enrolled, 10 were only TST positive; 8 were TST or/and IGRA positive. We found that participants testing positive at TST and/or IGRA, a group in which the risk of false LTBI positives is minimal, were older and had been studying longer. Although the prevalence of LTBI among dental students in our study was low, a risk of acquiring a work-related infection exists even in a country with a low incidence of TB. Thus, dental students should be screened to catch LTBI early on.

摘要

为了评估与牙科保健人员面临相同职业风险的意大利牙科学生中潜伏性结核感染(LTBI)的患病率,并评估潜在风险因素,对本科和研究生进行了一项横断面研究。经过临床评估后,学生们接受了结核菌素皮肤试验;对结果呈阳性者进行了γ-干扰素释放试验(IGRA)。在纳入研究的281名学生中,10名仅结核菌素皮肤试验呈阳性;8名结核菌素皮肤试验或/和γ-干扰素释放试验呈阳性。我们发现,结核菌素皮肤试验和/或γ-干扰素释放试验呈阳性的参与者年龄较大且学习时间较长,而该组中LTBI假阳性的风险最小。尽管我们研究中牙科学生的LTBI患病率较低,但即使在结核病发病率较低的国家,也存在因工作感染的风险。因此,应对牙科学生进行筛查以便早期发现LTBI。

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