鱼类学习：从斑马鱼造血过程洞察血液发育与血液疾病
Fish to Learn: Insights into Blood Development and Blood Disorders from Zebrafish Hematopoiesis.
作者信息
Avagyan Serine, Zon Leonard I
机构信息
1 Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute , Boston, Massachusetts.
2 Howard Hughes Medical Institute, Harvard Stem Cell Institute , Harvard Medical School, Boston, Massachusetts.
出版信息
Hum Gene Ther. 2016 Apr;27(4):287-94. doi: 10.1089/hum.2016.024.
Abstract
Since its introduction in early 1980s, the zebrafish (Danio rerio) has become an invaluable vertebrate animal model system to study many human disorders in almost all systems, from hepatic and brain pathology, to autoimmune and psychiatric disorders. Hematopoiesis between zebrafish and mammals is highly conserved, making the zebrafish an attractive model to study hematopoietic development and blood disorders. Unique attributes of the zebrafish include the ability to perform large-scale genetic and chemical screens in vivo, study development at the cellular level, and use transgenic fish to dissect mechanisms of disease or drug effects. This review summarizes major discoveries that helped define molecular control of hematopoiesis in vertebrates and specific contributions from studies in zebrafish.
摘要
自20世纪80年代初被引入以来，斑马鱼（Danio rerio）已成为一种极其宝贵的脊椎动物模型系统，可用于研究几乎所有系统中的许多人类疾病，从肝脏和脑部病理学，到自身免疫性和精神疾病。斑马鱼与哺乳动物之间的造血过程高度保守，这使得斑马鱼成为研究造血发育和血液疾病的有吸引力的模型。斑马鱼的独特特性包括能够在体内进行大规模遗传和化学筛选、在细胞水平研究发育，以及使用转基因鱼剖析疾病机制或药物作用。本综述总结了有助于确定脊椎动物造血分子控制的主要发现以及斑马鱼研究的具体贡献。
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本文引用的文献
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Exp Hematol. 2015 Dec;43(12):1047-61. doi: 10.1016/j.exphem.2015.09.001. Epub 2015 Sep 21.
2
Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment.环氧二十碳三烯酸可增强胚胎造血及成年骨髓植入。
Nature. 2015 Jul 23;523(7561):468-71. doi: 10.1038/nature14569.
3
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Leukemia. 2015 Dec;29(12):2355-65. doi: 10.1038/leu.2015.154. Epub 2015 Jun 24.
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Dev Cell. 2015 Mar 23;32(6):756-64. doi: 10.1016/j.devcel.2015.01.032. Epub 2015 Mar 5.
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