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[衰弱与肌肉减少症:通往痴呆症的新桥梁]

[Frailty and sarcopenia: a new bridge to dementia].

作者信息

Saji Naoki, Arai Hidenori, Sakurai Takashi, Toba Kenji

出版信息

Nihon Rinsho. 2016 Mar;74(3):505-9.

Abstract

Frailty is a predictor of functional decline, falls, hospitalization, and mortality. Fried et al. developed the frailty index, which include 5 simple items: weight loss, weakness, exhaustion, slowness, and low activity. Likewise, sarcopenia indicates an age-related decline in skeletal muscle mass as well as muscle function, which may result in reduced physical capability, poorer quality of life, impaired cardiopulmonary performance, unfavorable metabolic effects, falls, disability, and mortality. Both frailty and sarcopenia could be associated with mild cognitive impairment which leads to dementia. Thus, early initiation of a comprehensive geriatric health examination and a multidomain intervention such as diet, exercise, cognitive training, and vascular risk monitoring may be useful to prevent frailty and sarcopenia in community-dwelling older adults.

摘要

衰弱是功能衰退、跌倒、住院和死亡的一个预测指标。弗里德等人制定了衰弱指数,其中包括5个简单项目:体重减轻、虚弱、疲惫、行动迟缓以及活动量低。同样,肌少症表明骨骼肌质量以及肌肉功能出现与年龄相关的衰退,这可能导致身体能力下降、生活质量变差、心肺功能受损、代谢效应不佳、跌倒、残疾和死亡。衰弱和肌少症都可能与导致痴呆症的轻度认知障碍有关。因此,尽早开展全面的老年健康检查以及饮食、运动、认知训练和血管风险监测等多领域干预措施,可能有助于预防社区居住老年人的衰弱和肌少症。

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