猫免疫缺陷病毒在淋巴瘤发生中的作用——单独作用还是协同作用？

Role of Feline Immunodeficiency Virus in Lymphomagenesis--Going Alone or Colluding?

作者信息

Kaye Sarah, Wang Wenqi, Miller Craig, McLuckie Alicia, Beatty Julia A, Grant Chris K, VandeWoude Sue, Bielefeldt-Ohmann Helle

机构信息

Sarah Kaye, BVSc, is a small animal clinician with the Animal Welfare League Qld Inc. in The Gold Coast, Queensland, Australia. Wenqi Wang, BVSc, PhD, is a postdoctoral fellow affiliated with the School of Veterinary Science at University of Queensland at Gatton in Australia. Craig Miller, DVM, is a postdoctoral fellow in the Department of Microbiology, Immunology & Pathology at Colorado State University in FortCollins, Colorado. Alicia McLuckie, BVSc, is a PhD candidate in the Faculty of Veterinary Science at the University of Sydney in NSW, Australia, Julia A. Beatty, BSc, BVetMed, PhD, FANZCVs (feline med), is a professor in the Faculty of Veterinary Science at the University of Sydney in NSW, Australia. Chris K. Grant, PhD, DSc, is founder and CEO of Custom Monoclonals International Corp. in West Sacramento, California. Sue VandeWoude, DVM, MS, DACLAM, is a professor in the Department of Microbiology, Immunology & Pathology at Colorado State University and Associate Dean for Research in the College of Veterinary & Biomedical Sciences at Colorado State University in Fort Collins, Colorado. Helle Bielefeldt-Ohmann, DVM, PhD, is a senior lecturer in the School of Veterinary Science at the University of Queensland at Gatton, an affiliate senior lecturer in the School of Chemistry & Molecular Biosciences at the University of Queensland at St. Lucia, and an investigator at the Australian Infectious Diseases Research Centre at the University of Queensland in St. Lucia, Australia.

出版信息

ILAR J. 2016;57(1):24-33. doi: 10.1093/ilar/ilv047.

DOI:10.1093/ilar/ilv047

PMID:27034392

Abstract

Feline immunodeficiency virus (FIV) is a naturally occurring lentivirus of domestic and nondomestic feline species. Infection in domestic cats leads to immune dysfunction via mechanisms similar to those caused by human immunodeficiency virus (HIV) and, as such, is a valuable natural animal model for acquired immunodeficiency syndrome (AIDS) in humans. An association between FIV and an increased incidence of neoplasia has long been recognized, with frequencies of up to 20% in FIV-positive cats recorded in some studies. This is similar to the rate of neoplasia seen in HIV-positive individuals, and in both species neoplasia typically requires several years to arise. The most frequently reported type of neoplasia associated with FIV infection is lymphoma. Here we review the possible mechanisms involved in FIV lymphomagenesis, including the possible involvement of coinfections, notably those with gamma-herpesviruses.

摘要

猫免疫缺陷病毒（FIV）是一种存在于家养和非家养猫科动物中的自然发生的慢病毒。家猫感染该病毒会通过与人类免疫缺陷病毒（HIV）引起免疫功能障碍的机制相似的途径导致免疫功能失调，因此，它是人类获得性免疫缺陷综合征（AIDS）的一种有价值的天然动物模型。FIV与肿瘤发生率增加之间的关联早已得到认可，一些研究记录显示FIV阳性猫的肿瘤发生率高达20%。这与HIV阳性个体中肿瘤的发生率相似，并且在这两个物种中，肿瘤通常需要数年时间才会出现。与FIV感染相关的最常报道的肿瘤类型是淋巴瘤。在此，我们综述了FIV淋巴瘤发生可能涉及的机制，包括合并感染（尤其是与γ-疱疹病毒的合并感染）可能发挥的作用。