接受体外生命支持的成年患者的治疗性低温：一项随机对照研究的早期结果。
Therapeutic hypothermia in adult patients receiving extracorporeal life support: early results of a randomized controlled study.
作者信息
Pang Philip Y K, Wee Gillian H L, Hoo Anne E E, Sheriff Ismail Mohamed Tahir, Lim See Lim, Tan Teing Ee, Loh Yee Jim, Kerk Ka Lee, Sin Yoong Kong, Lim Chong Hee
机构信息
Department of Cardiothoracic Surgery, National Heart Centre Singapore, 5 Hospital Drive, 169609, ᅟ, Singapore.
Cardiothoracic Intensive Care Unit, National Heart Centre Singapore, ᅟ, Singapore.
出版信息
J Cardiothorac Surg. 2016 Apr 5;11:43. doi: 10.1186/s13019-016-0437-8.
Abstract
Cardiac arrest with cerebral ischaemia frequently leads to severe neurological impairment. Extracorporeal life support (ECLS) has emerged as a valuable adjunct in resuscitation of cardiac arrest. Despite ECLS, the incidence of permanent neurological injury remains high. We hypothesize that patients receiving ECLS for cardiac arrest treated with therapeutic hypothermia at 34 °C have lower neurological complication rates compared to standard ECLS therapy at normothermia. Early results of this randomized study suggest that therapeutic hypothermia is safe in adult patients receiving ECLS, with similar complication rates as ECLS without hypothermia. Further studies are warranted to measure the efficacy of this therapy.
摘要
心脏骤停合并脑缺血常导致严重的神经功能障碍。体外生命支持（ECLS）已成为心脏骤停复苏中有价值的辅助手段。尽管有ECLS，但永久性神经损伤的发生率仍然很高。我们假设，与常温下的标准ECLS治疗相比，接受34°C治疗性低温的心脏骤停患者接受ECLS时神经并发症发生率更低。这项随机研究的早期结果表明，治疗性低温在接受ECLS的成年患者中是安全的，并发症发生率与未进行低温治疗的ECLS相似。有必要进行进一步研究以评估该疗法的疗效。
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