Bucher Brian T, Duggan Eileen M, Grubb Peter H, France Daniel J, Lally Kevin P, Blakely Martin L
Division of Pediatric Surgery, Department of Surgery, University of Utah School of Medicine, 100 North Mario Capecchi Drive, Suite #3800, Salt Lake City, UT 84113-1103, USA.
Department of Pediatric Surgery, Section of Surgical Sciences, Vanderbilt University School of Medicine, 7100 Doctors' Office Tower, 2200 Children's Way, Nashville, TN 37232, USA.
J Pediatr Surg. 2016 Sep;51(9):1440-4. doi: 10.1016/j.jpedsurg.2016.02.084. Epub 2016 Mar 10.
BACKGROUND/PURPOSE: The purpose of this project was to examine the American College of Surgeons National Surgical Quality Improvement Program Pediatric (ACSNSQIP-P) Participant Use File (PUF) to compare risk-adjusted outcomes of neonates versus other pediatric surgical patients.
In the ACS-NSQIP-P 2012-2013 PUF, patients were classified as preterm neonate, term neonate, or nonneonate at the time of surgery. The primary outcomes were 30-day mortality and composite morbidity. Patient characteristics significantly associated with the primary outcomes were used to build a multivariate logistic regression model.
The overall 30-day mortality rate for preterm neonates, term neonate, and nonneonates was 4.9%, 2.0%, 0.1%, respectively (p<0.0001). The overall 30-day morbidity rate for preterm neonates, term neonates, and nonneonates was 27.0%, 17.4%, 6.4%, respectively (p<0.0001). After adjustment for preoperative and operative risk factors, both preterm (adjusted odds ratio, 95% CI: 2.0, 1.4-3.0) and term neonates (aOR, 95% CI: 1.9, 1.2-3.1) had a significantly increased odds of 30-day mortality compared to nonneonates.
Surgical neonates are a cohort who are particularity susceptible to postoperative morbidity and mortality after adjusting for preoperative and operative risk factors. Collaborative efforts focusing on surgical neonates are needed to understand the unique characteristics of this cohort and identify the areas where the morbidity and mortality can be improved.
背景/目的:本项目旨在研究美国外科医师学会国家外科质量改进计划儿科版(ACSNSQIP-P)参与者使用文件(PUF),以比较新生儿与其他儿科手术患者的风险调整后结局。
在ACS-NSQIP-P 2012 - 2013年PUF中,患者在手术时被分类为早产新生儿、足月儿或非新生儿。主要结局为30天死亡率和综合发病率。将与主要结局显著相关的患者特征用于构建多因素逻辑回归模型。
早产新生儿、足月儿和非新生儿的总体30天死亡率分别为4.9%、2.0%、0.1%(p<0.0001)。早产新生儿、足月儿和非新生儿的总体30天发病率分别为27.0%、17.4%、6.4%(p<0.0001)。在对术前和手术风险因素进行调整后,与非新生儿相比,早产新生儿(调整优势比,95%CI:2.0,1.4 - 3.0)和足月儿(aOR,95%CI:1.9,1.2 - 3.1)的30天死亡几率均显著增加。
手术新生儿是一个在调整术前和手术风险因素后特别容易发生术后发病和死亡的队列。需要共同努力关注手术新生儿,以了解该队列的独特特征,并确定可以改善发病和死亡情况的领域。