姜黄素通过抑制EZH2和NOTCH1对肺癌产生抗癌作用。
Anti-cancer effects of curcumin on lung cancer through the inhibition of EZH2 and NOTCH1.
作者信息
Wu Guo-Qing, Chai Ke-Qun, Zhu Xiu-Ming, Jiang Hua, Wang Xiao, Xue Qian, Zheng Ai-Hong, Zhou Hong-Ying, Chen Yun, Chen Xiao-Chen, Xiao Jian-Yong, Ying Xu-Hua, Wang Fu-Wei, Rui Tao, Liao Yi-Ji, Xie Dan, Lu Li-Qin, Huang Dong-Sheng
机构信息
Department of Oncology and Cancer Biotherapy Center, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, China.
Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, China.
出版信息
Oncotarget. 2016 May 3;7(18):26535-50. doi: 10.18632/oncotarget.8532.
Curcumin is potentially therapeutic for malignant diseases. The mechanisms of this effect might involve a combination of antioxidant, immunomodulatory, proapoptotic, and antiangiogenic activities. However, the exact mechanisms are not fully understood. In the present study, we provided evidences that curcumin suppressed the expression of enhancer of zeste homolog 2 (EZH2) in lung cancer cells both transcriptionally and post-transcriptionally. Curcumin inhibited the expression of EZH2 through microRNA (miR)-let 7c and miR-101. Curcumin decreased the expression of NOTCH1 through the inhibition of EZH2. There was a reciprocal regulation between EZH2 and NOTCH1 in lung cancer cells. These observations suggest that curcumin inhibits lung cancer growth and metastasis at least partly through the inhibition of EZH2 and NOTCH1.
姜黄素对恶性疾病具有潜在的治疗作用。这种作用机制可能涉及抗氧化、免疫调节、促凋亡和抗血管生成活性的综合作用。然而，确切机制尚未完全明确。在本研究中，我们提供证据表明姜黄素在转录和转录后水平均抑制肺癌细胞中zeste同源物2（EZH2）增强子的表达。姜黄素通过微小RNA（miR）-let 7c和miR-101抑制EZH2的表达。姜黄素通过抑制EZH2降低NOTCH1的表达。在肺癌细胞中，EZH2和NOTCH1之间存在相互调节。这些观察结果表明，姜黄素至少部分通过抑制EZH2和NOTCH1来抑制肺癌的生长和转移。
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