氧化石墨烯掺杂细菌纤维素/聚（3,4-乙撑二氧噻吩）纳米纤维上细胞生长形成的生物界面
Biointerface by Cell Growth on Graphene Oxide Doped Bacterial Cellulose/Poly(3,4-ethylenedioxythiophene) Nanofibers.
作者信息
Chen Chuntao, Zhang Ting, Zhang Qi, Chen Xiao, Zhu Chunlin, Xu Yunhua, Yang Jiazhi, Liu Jian, Sun Dongping
机构信息
Institute of Chemicobiology and Functional Materials, School of Chemical Engineering, Nanjing University of Science and Technology , 200 Xiao Ling Wei Street, Nanjing, Jiangsu Province, China.
Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University , 199 Ren Ai Road, Suzhou Industrial Park, Suzhou, Jiangsu Province, China.
出版信息
ACS Appl Mater Interfaces. 2016 Apr 27;8(16):10183-92. doi: 10.1021/acsami.6b01243. Epub 2016 Apr 14.
Highly biocompatible advanced materials with excellent electroactivity are increasingly meaningful to biointerfaces and the development of biomedicine. Herein, bacterial cellulose/poly(3,4-ethylene dioxythiophene)/graphene oxide (BC/PEDOT/GO) composite nanofibers were synthesized through the in situ interfacial polymerization of PEDOT with the doping of GO. The abundant free carboxyl and hydroxy groups offer the BC/PEDOT/GO film active functional groups for surface modification. We demonstrate the use of this composite nanofiber for the electrical stimulation of PC12 neural cells as this resultant nanofiber scaffold could closely mimic the structure of the native extracellular matrix (ECM) with a promoting cell orientation and differentiation after electrical stimulation of PC12 cells. It is expected that this biocompatible BC/PEDOT/GO material will find potential applications in biological and regenerative medicine.
具有优异电活性的高生物相容性先进材料对生物界面和生物医药的发展越来越重要。在此，通过PEDOT的原位界面聚合并掺杂氧化石墨烯（GO）合成了细菌纤维素/聚（3,4-乙撑二氧噻吩）/氧化石墨烯（BC/PEDOT/GO）复合纳米纤维。丰富的游离羧基和羟基为BC/PEDOT/GO薄膜提供了用于表面修饰的活性官能团。我们展示了这种复合纳米纤维用于对PC12神经细胞进行电刺激，因为这种所得的纳米纤维支架可以紧密模拟天然细胞外基质（ECM）的结构，在对PC12细胞进行电刺激后促进细胞定向和分化。预计这种生物相容性的BC/PEDOT/GO材料将在生物和再生医学中找到潜在应用。
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