羊水快速生物标志物与早产妊娠的羊膜腔内感染有关，无论胎膜状态如何。
Amniotic fluid rapid biomarkers are associated with intra-amniotic infection in preterm pregnancies regardless of the membrane status.
作者信息
Myntti T, Rahkonen L, Tikkanen M, Pätäri-Sampo A, Paavonen J, Stefanovic V
机构信息
Department of Obstetrics and Gynecology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Division of Clinical Microbiology, HUSLAB, Helsinki University Hospital, Helsinki, Finland.
出版信息
J Perinatol. 2016 Aug;36(8):606-11. doi: 10.1038/jp.2016.59. Epub 2016 Apr 7.
OBJECTIVE
The objective of this study was to evaluate the association of amniotic fluid lactate dehydrogenase and glucose concentrations with microbial invasion of amniotic cavity and histologic chorioamnionitis before 37 pregnancy weeks in women with or without preterm premature rupture of membranes.
STUDY DESIGN
Amniocentesis was performed on 70 women with suspected intra-amniotic infection. Standard biochemical methods, molecular microbiology and culture techniques were used. Histopathological examination of the placenta was performed.
RESULTS
Thirty (48%) women had microbial invasion of the amniotic cavity (MIAC), 53 (76%) women had histological chorioamnionitis and 28 women had both. The cutoff values for MIAC and histological chorioamnionitis were 429 IU l(-1) for lactate dehydrogenase and 0.7 mmol l(-1) for glucose. Both end points occurred equally often regardless of the membrane status.
CONCLUSION
Increased amniotic fluid lactate dehydrogenase and decreased glucose were associated with MIAC and histological chorioamnionitis. However, test performance was of limited value.
目的
本研究的目的是评估妊娠37周前有或无早产胎膜早破的女性羊水中乳酸脱氢酶和葡萄糖浓度与羊膜腔微生物入侵及组织学绒毛膜羊膜炎之间的关联。
研究设计
对70例疑似羊膜腔内感染的女性进行羊膜腔穿刺。采用标准生化方法、分子微生物学和培养技术。对胎盘进行组织病理学检查。
结果
30例（48%）女性发生羊膜腔微生物入侵（MIAC），53例（76%）女性发生组织学绒毛膜羊膜炎，28例女性两者均有。MIAC和组织学绒毛膜羊膜炎的乳酸脱氢酶临界值为429 IU l⁻¹，葡萄糖临界值为0.7 mmol l⁻¹。无论胎膜状态如何，两个终点事件发生的频率相同。
结论
羊水乳酸脱氢酶升高和葡萄糖降低与MIAC和组织学绒毛膜羊膜炎有关。然而，检测性能的价值有限。
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