Lee Young-Ah Lucy, Zhang Shiyi, Lin Jiaqi, Langer Robert, Traverso Giovanni
Department of Chemical Engineering and Koch Institute for Integrative Cancer, Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Harvard-MIT Division of Health Sciences and Technology, Institute of Technology, Massachusetts, Cambridge, MA, 02139, USA.
Adv Healthc Mater. 2016 May;5(10):1141-6. doi: 10.1002/adhm.201501036. Epub 2016 Apr 6.
A novel Janus device with omniphobic and mucoadhesive sides that exhibit the unique capacity for antifouling and extended gastrointestinal retention is fabricated. This system enables repulsion of the food and fluid stream by the luminal-facing omniphobic side and allows attachment to the gastrointestinal mucosa by the mucoadhesive side.
制备了一种新型的双面装置,其一面具有疏液性,另一面具有粘膜粘附性,展现出独特的防污和延长胃肠道滞留能力。该系统通过面向管腔的疏液性一面排斥食物和液流,并通过粘膜粘附面附着于胃肠道粘膜。