锝-亚甲基二膦酸盐治疗类风湿性关节炎、脉络膜新生血管形成和格雷夫斯眼病。
Tc-MDP treatment for the therapy of rheumatoid arthritis, choroidal neovascularisation and Graves' ophthalmopathy.
作者信息
Wu Qian, Ni Yang, Yang Qingrui, Sun Hongsheng
机构信息
Department of Rheumatology and Immunology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China.
Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China.
出版信息
Biomed Rep. 2016 Apr;4(4):400-402. doi: 10.3892/br.2016.609. Epub 2016 Feb 23.
Abstract
Technetium 99 conjugated with methylene diphosphonate, which is an anti-inflammatory drug, can inhibit macrophage infiltration and downregulate a number of proinflammatory cytokines, such as tumor necrosis factor-α and interleukin-1β. Recently, numerous studies have indicated that it could improve rheumatoid arthritis (RA) activity by upregulating the frequency of peripheral γδ T cells and cluster of differentiation CD4CD25Foxp3 Tregs, affecting the serum cytokine environment, inhibiting osteoclast formation and reducing the concentrations of rheumatoid factor-immunoglobulin M (IgM)/IgG/IgA. As well, it may have a therapeutic role for choroidal neovascularisation (CNV) and Graves' ophthalmopathy (GO). Therefore, it will be a valuable choice in the treatment of RA, CNV and GO.
摘要
锝99与亚甲基二膦酸盐结合，亚甲基二膦酸盐是一种抗炎药物，可抑制巨噬细胞浸润并下调多种促炎细胞因子，如肿瘤坏死因子-α和白细胞介素-1β。最近，大量研究表明，它可通过上调外周γδT细胞和分化簇CD4CD25Foxp3调节性T细胞的频率、影响血清细胞因子环境、抑制破骨细胞形成以及降低类风湿因子免疫球蛋白M（IgM）/IgG/IgA的浓度来改善类风湿性关节炎（RA）的活动。此外，它可能对脉络膜新生血管形成（CNV）和格雷夫斯眼病（GO）具有治疗作用。因此，它将是治疗RA、CNV和GO的宝贵选择。
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