Roberts William C, Moore Meagan, Ko Jong Mi, Hamman Baron L
Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas; Department of Internal Medicine (Division of Cardiology), Baylor University Medical Center, Dallas, Texas; Department of Pathology, Baylor University Medical Center, Dallas, Texas.
Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas; Second Year, Texas A&M University, College Station, Texas.
Am J Cardiol. 2016 Jun 1;117(11):1790-807. doi: 10.1016/j.amjcard.2016.03.014. Epub 2016 Mar 19.
Mitral repair operations for correction of pure mitral regurgitation (MR) are generally quite successful. Occasionally, however, the reparative procedure incompletely corrects the MR or the MR recurs. From March 1993 to January 2016, twenty nine patients had mitral valve replacement after the initial mitral repair operation, and observations in them were analyzed. All 29 patients at the repair operation had an annular ring inserted and later (<1 year in 6 and >1 year in 21) mitral valve replacement. The cause of the MR before the repair operation appears to have been prolapse in 16 patients (55%), secondary (functional) in 12 (41%) (ischemic in 5), and infective endocarditis which healed in 1 (3%). At the replacement operation the excised anterior mitral leaflet was thickened in all 29 patients. Some degree of stenosis appeared to have been present in 16 of the 29 patients before the replacement operation, although only 10 had an echocardiographic or hemodynamic recording of a transvalvular gradient; at least 11 patients had restricted motion of the posterior mitral leaflet; 10, ring dehiscence; 2, severe hemolysis; and 2, left ventricular outflow obstruction. In conclusion, there are multiple reasons for valve replacement after earlier mitral repair. Uniformly, at the time of the replacement, the mitral leaflets were thickened by fibrous tissue. Measurement of the area enclosed by the 360° rings and study of the excised leaflet suggest that the ring itself may have contributed to the leaflet scarring and development of some transmitral stenosis.
用于纠正单纯二尖瓣反流(MR)的二尖瓣修复手术通常相当成功。然而,偶尔修复手术并不能完全纠正MR或MR复发。从1993年3月至2016年1月,29例患者在初次二尖瓣修复手术后进行了二尖瓣置换,并对他们的情况进行了分析。所有29例患者在修复手术时均植入了瓣环,随后(6例<1年,21例>1年)进行了二尖瓣置换。修复手术前MR的原因似乎是16例患者(55%)为脱垂,12例(41%)为继发性(功能性)(5例为缺血性),1例(3%)为感染性心内膜炎已治愈。在置换手术时,所有29例患者切除的二尖瓣前叶均增厚。置换手术前,29例患者中有16例似乎存在某种程度的狭窄,尽管只有10例有经超声心动图或血流动力学记录的跨瓣压差;至少11例患者二尖瓣后叶活动受限;10例有瓣环裂开;2例有严重溶血;2例有左心室流出道梗阻。总之,早期二尖瓣修复后进行瓣膜置换有多种原因。一致的是,在置换时,二尖瓣叶被纤维组织增厚。测量360°瓣环所围面积并研究切除的瓣叶表明,瓣环本身可能导致了瓣叶瘢痕形成和一些二尖瓣狭窄的发展。