Yan Shanshan, Miller Marvin J, Wencewicz Timothy A, Möollmann Ute
Department of Chemistry and Biochemistry, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, Indiana, 46556, USA. ; Tel: +1 574 631 7571.
Leibniz Institute for Natural Products Research and Infection Biology - Hans Knöell Institute, Beutenbergstrasse 11a, D-07745 Jena, Germany.
Medchemcomm. 2010 Aug 1;1(2):145-148. doi: 10.1039/C0MD00015A. Epub 2010 May 5.
Two cephalosporin-oxazolidinone conjugates were synthesized by incorporation of a carbamate linker at the 3'-position of the cephalosporin. These compounds show stability in aqueous media until specifically activated by a β-lactamase, and retain antibacterial activities profiles reflecting both the individual cephalosporin and oxazolidinone components.
通过在头孢菌素的3'-位引入氨基甲酸酯连接基,合成了两种头孢菌素-恶唑烷酮缀合物。这些化合物在水性介质中表现出稳定性,直到被β-内酰胺酶特异性激活,并且保留了反映单个头孢菌素和恶唑烷酮组分的抗菌活性谱。