Department of Physiological Sciences, Center for Veterinary Health Sciences, Oklahoma State University , Stillwater, OK , USA.
Purina Animal Nutrition, Land O'Lakes Inc , Gray Summit, MO , USA.
Front Vet Sci. 2016 Apr 4;3:30. doi: 10.3389/fvets.2016.00030. eCollection 2016.
Gastritis and gastric ulcers are an important cause of morbidity and mortality in canine athletes. Although the majority of scientific work on this condition has been performed in ultraendurance racing sled dogs, this condition has been identified in other canine athletes, including sled dogs competing in shorter events and dogs performing off-leash explosive detection duties. The cause of the syndrome is unknown, but current hypotheses propose a link between exercise-induced hyperthermia and loss of gastric mucosal barrier function as an early event in the pathogenesis. Treatment is focused on prevention of clinical disease using acid secretion inhibitors, such as omeprazole, which has excellent efficacy in controlled clinical studies.
胃炎和胃溃疡是犬类运动员发病率和死亡率的一个重要原因。虽然大多数关于这种疾病的科学研究都是在超耐力赛雪橇犬中进行的,但这种疾病也在其他犬类运动员中被发现,包括在较短的比赛中竞争的雪橇犬和执行无绳爆炸物探测任务的犬。该综合征的病因尚不清楚,但目前的假说提出,运动引起的体温过高与胃黏膜屏障功能丧失之间存在联系,这是发病机制中的早期事件。治疗的重点是使用胃酸分泌抑制剂预防临床疾病,如奥美拉唑,在对照临床试验中疗效良好。