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[乳房植入物相关间变性大细胞淋巴瘤。一例未确诊形式的病例报告、处理及重建(ALCL)]

[Breast implant-associated anaplastic large cell lymphoma. Case report of an undiagnosed form, management and reconstruction (ALCL)].

作者信息

Alhamad S, Guerid S, El Fakir E H, Biron P, Tourasse C, Delay E

机构信息

Unité de chirurgie plastique et reconstructrice, centre Léon-Bérard, 28, rue Laënnec, 69373 Lyon cedex 08, France.

Unité de chirurgie plastique et reconstructrice, centre Léon-Bérard, 28, rue Laënnec, 69373 Lyon cedex 08, France.

出版信息

Ann Chir Plast Esthet. 2016 Jun;61(3):223-30. doi: 10.1016/j.anplas.2016.03.003. Epub 2016 Apr 20.

Abstract

Breast implant-associated anaplastic large cell lymphoma (ALCL) is an extremely rare disease. Is a new nosologic entity with a multifactorial origin and a wide occurrence delay after breast implantation. This article reports the case of a 60 years old patient with a progressive swelling of the right breast after aesthetic breast implants. Diagnostic was delayed because first surgeon was not familiar with the disease. Patient was then referred to us for management. We performed an implant removal and a complete capsulectomy. Pathologic report confirms the diagnostic. After one year and normal ultrasound evaluation, we reconstructed the breast with lipomodeling and mastopexy. Contralateral implant was also removed at time of reconstruction. Vast majority of breast implant-associated ALCL occurs at a time lapse of 11 to 15 years after implant augmentation, with a mean age of 63 years. Among the worldwide 173 cases reported in March 2015, smooth implants seem not to be at risk but 80% of cases were associated with macrotexturized implants. Clinical presentation and diagnostic tools are more and more published but there is to date no recommendation concerning reconstruction delay after implant removal for this pathology. We advise the realization of a breast ultrasound every three months during the first year and wait for a one-year period before reconstruction. In case of aesthetic surgery, mastopexia can be done to allow for glandular shaping. Lipomodeling is an excellent technique to correct the lack of volume due to implant removal. In case of reconstructive setting, implant can be replaced by flap procedure with lipomodeling if needed or lipomodeling alone if recipient site is favorable and patient has enough fat tissue. Contralateral implant should be removed during reconstruction time.

摘要

乳房植入物相关间变性大细胞淋巴瘤(ALCL)是一种极其罕见的疾病。它是一种新的病种,起源多因素,且在乳房植入后出现延迟时间较长。本文报告了一例60岁患者,在进行美容性乳房植入后右乳出现进行性肿胀。诊断延迟是因为首位外科医生不熟悉该疾病。患者随后被转诊至我们处进行治疗。我们进行了植入物取出和完整的包膜切除术。病理报告证实了诊断。在一年且超声评估正常后,我们采用脂肪塑形和乳房上提术对乳房进行了重建。在重建时也取出了对侧植入物。绝大多数乳房植入物相关ALCL发生在植入增大后11至15年,平均年龄为63岁。在2015年3月报告的全球173例病例中,光滑植入物似乎没有风险,但80%的病例与大纹理植入物有关。关于这种病理情况,临床症状和诊断工具的报道越来越多,但迄今为止对于植入物取出后重建延迟尚无建议。我们建议在第一年每三个月进行一次乳房超声检查,并在重建前等待一年时间。在进行美容手术时,可以进行乳房上提术以实现腺体塑形。脂肪塑形是纠正因植入物取出导致的体积不足的一种极佳技术。在进行重建手术时,如果需要,可以采用带脂肪塑形的皮瓣手术替代植入物,或者如果受区合适且患者有足够的脂肪组织,也可以单独进行脂肪塑形。在重建时应取出对侧植入物。

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