人诱导多能干细胞衍生的心肌细胞为遗传性心血管疾病建模带来新机遇。
Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Afford New Opportunities in Inherited Cardiovascular Disease Modeling.
作者信息
Bayzigitov Daniel R, Medvedev Sergey P, Dementyeva Elena V, Bayramova Sevda A, Pokushalov Evgeny A, Karaskov Alexander M, Zakian Suren M
机构信息
Federal Research Center, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Academy Lavrentyev Avenue 10, Novosibirsk 630090, Russia; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Academy Lavrentyev Avenue 8, Novosibirsk 630090, Russia; State Research Institute of Circulation Pathology, Rechkunovskaya Street 15, Novosibirsk 630055, Russia.
Federal Research Center, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Academy Lavrentyev Avenue 10, Novosibirsk 630090, Russia; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Academy Lavrentyev Avenue 8, Novosibirsk 630090, Russia; State Research Institute of Circulation Pathology, Rechkunovskaya Street 15, Novosibirsk 630055, Russia; Novosibirsk State University, Pirogova Street 2, Novosibirsk 630090, Russia.
出版信息
Cardiol Res Pract. 2016;2016:3582380. doi: 10.1155/2016/3582380. Epub 2016 Mar 27.
Fundamental studies of molecular and cellular mechanisms of cardiovascular disease pathogenesis are required to create more effective and safer methods of their therapy. The studies can be carried out only when model systems that fully recapitulate pathological phenotype seen in patients are used. Application of laboratory animals for cardiovascular disease modeling is limited because of physiological differences with humans. Since discovery of induced pluripotency generating induced pluripotent stem cells has become a breakthrough technology in human disease modeling. In this review, we discuss a progress that has been made in modeling inherited arrhythmias and cardiomyopathies, studying molecular mechanisms of the diseases, and searching for and testing drug compounds using patient-specific induced pluripotent stem cell-derived cardiomyocytes.
为了创造更有效、更安全的心血管疾病治疗方法，需要对心血管疾病发病机制的分子和细胞机制进行基础研究。只有使用能够完全重现患者病理表型的模型系统，才能开展这些研究。由于与人类存在生理差异，实验室动物在心血管疾病建模中的应用受到限制。自从发现诱导多能性从而产生诱导多能干细胞以来，这已成为人类疾病建模中的一项突破性技术。在这篇综述中，我们讨论了在利用患者特异性诱导多能干细胞衍生的心肌细胞对遗传性心律失常和心肌病进行建模、研究疾病的分子机制以及寻找和测试药物化合物方面所取得的进展。
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