血管活性肠多肽刺激灌流大鼠十二指肠中的胆囊收缩素分泌。

Vasoactive intestinal polypeptide stimulates cholecystokinin secretion in perfused rat duodenum.

作者信息

Funakoshi A, Nakano I, Miyazaki K

机构信息

National Kyushu Cancer Center, Fukuoka, Japan.

出版信息

Tohoku J Exp Med. 1989 Jan;157(1):55-9. doi: 10.1620/tjem.157.55.

DOI:10.1620/tjem.157.55

PMID:2711376

Abstract

We examined the effect of vasoactive intestinal polypeptide (VIP) on cholecystokinin (CCK) secretion from the isolated perfused rat duodenum. VIP stimulated CCK secretion mono-phasically in a concentration-dependent manner in concentrations ranging from 10(-9) to 10(-7) M, and 10(-7) M of VIP led to an increment of 82 +/- 25.8 fmole/3 min. The stimulatory effect of VIP on CCK was not inhibited by 10(-5) M atropine. These results suggest that VIP may directly stimulate CCK secretion from the duodenum and work as a non-cholinergic, peptidergic neurotransmitter.

摘要

我们研究了血管活性肠肽（VIP）对离体灌注大鼠十二指肠胆囊收缩素（CCK）分泌的影响。VIP以浓度依赖性方式单时相刺激CCK分泌，浓度范围为10⁻⁹至10⁻⁷M，10⁻⁷M的VIP导致增加82±25.8飞摩尔/3分钟。VIP对CCK的刺激作用不受10⁻⁵M阿托品的抑制。这些结果表明，VIP可能直接刺激十二指肠CCK分泌，并作为一种非胆碱能肽能神经递质发挥作用。