氯沙坦和氨氯地平对年轻易卒中自发性高血压大鼠左心室重构及功能的影响
Effects of Losartan and Amlodipine on Left Ventricular Remodeling and Function in Young Stroke-Prone Spontaneously Hypertensive Rats.
作者信息
He De-Hua, Zhang Liang-Min, Lin Li-Ming, Ning Ruo-Bing, Wang Hua-Jun, Xu Chang-Sheng, Lin Jin-Xiu
机构信息
Department of Cardiology, First Affiliated Hospital of Xiamen University; ; Department of Cardiology, First Clinical Medical College of Fujian Medical University, Fujian;
Department of Cardiology, People's Hospital of Ningdu County, Jiangxi;
出版信息
Acta Cardiol Sin. 2014 Jul;30(4):316-24.
BACKGROUND
The purpose of this study was to evaluate the effects of prehypertensive losartan and amlodipine administration on left ventricular (LV) remodeling and function in spontaneously hypertensive rats-stroke prone (SHRSP).
METHODS
Spontaneously hypertensive rats-stroke prone were prehypertensively administered losartan, amlodipine, or vehicle. Wistar-Kyoto rats were used as a control. Blood pressure of the rats was determined by tail-cuff method, and LV structure and function were measured by echocardiography and LV cannulation. Collagen volume fraction was analyzed by picrosirius red staining. Protein expressions of brain natriuretic peptide (BNP) and angiotensin II type 1 (AT1R) and type 2 (AT2R) receptors were determined by use of the Western blotting method.
RESULTS
Although both drugs downregulated BNP protein expression, the LV remodeling and function were more improved with losartan than with amlodipine treatment. Losartan upregulated AT1R and downregulated AT2R protein expression.
CONCLUSIONS
Both drugs inhibited LV remodeling and improved LV function in prehypertensively treated SHRSP. Losartan provided better continued heart protection, potentially due to its persistent inhibition of AT1R and activation of AT2R in the myocardium.
KEY WORDS
Amlodipine; Blood pressure; Heart; Losartan; Prehypertension.
背景
本研究旨在评估高血压前期给予氯沙坦和氨氯地平对易卒中型自发性高血压大鼠（SHRSP）左心室（LV）重构及功能的影响。
方法
对易卒中型自发性高血压大鼠进行高血压前期给药，分别给予氯沙坦、氨氯地平或赋形剂。以Wistar-Kyoto大鼠作为对照。采用尾套法测定大鼠血压，通过超声心动图和左心室插管测量左心室结构和功能。用苦味酸天狼星红染色分析胶原容积分数。采用蛋白质印迹法测定脑钠肽（BNP）、血管紧张素II 1型（AT1R）和2型（AT2R）受体的蛋白表达。
结果
尽管两种药物均下调了BNP蛋白表达，但氯沙坦治疗较氨氯地平治疗能更有效地改善左心室重构和功能。氯沙坦上调了AT1R蛋白表达，下调了AT2R蛋白表达。
结论
在高血压前期治疗的SHRSP中，两种药物均抑制了左心室重构并改善了左心室功能。氯沙坦提供了更好的持续性心脏保护作用，这可能归因于其对心肌中AT1R的持续抑制和对AT2R的激活。
关键词
氨氯地平；血压；心脏；氯沙坦；高血压前期
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