炎症和胰岛素抵抗的新指标与11至14岁不同样本青少年的肥胖和健康状况相关：健康研究
Novel measures of inflammation and insulin resistance are related to obesity and fitness in a diverse sample of 11-14 year olds: The HEALTHY Study.
作者信息
Jago R, Drews K L, Otvos J D, Willi S M, Buse J B
机构信息
Centre for Exercise, Nutrition & Health, School for Policy Studies, University of Bristol, Bristol, UK.
The George Washington University Biostatistics Center, Rockville, MD, USA.
出版信息
Int J Obes (Lond). 2016 Jul;40(7):1157-63. doi: 10.1038/ijo.2016.84. Epub 2016 May 4.
BACKGROUND
GlycA is a novel serum marker of systemic inflammation. There is no information on GlycA in pediatric populations, how it differs by gender or its association with body mass index (BMI) or fitness. Lipoprotein insulin resistance index (LP-IR) is a serum measure of insulin resistance, which is related to changes in BMI group in adolescents, but its relationship with fitness is unknown. The current study examined the independent associations between fitness and BMI with GlycA and LP-IR among US adolescents.
METHODS
Participants were 1664 US adolescents from the HEALTHY study with complete 6th and 8th grade BMI, fitness and blood data. GlycA and LP-IR were measured by nuclear magnetic resonance spectroscopy. Three BMI groups and three fitness groups were created. Linear mixed models examined associations between GlycA, LP-IR, fitness and BMI.
RESULTS
LP-IR decreased between 6th and 8th grade. GlycA increased among girls but decreased among boys. At 8th grade, median GlycA values were 27 (7.6%) μmol l(-1) higher (381 versus 354) for girls than boys. Median GlycA 6th grade values were 9% higher in obese girls than healthy weight girls. Overall, there was strong evidence (P<0.001) that GlycA was higher in higher BMI groups. Fitness was negatively associated with GlycA (r=-0.37 and -0.35) and LP-IR (r=-0.34 and -0.18) at the 6th and 8th grade assessments. As BMI category increased and fitness category decreased, GlycA and LP-IR levels increased. Lowest GlycA was found in the low BMI/high fitness group.
CONCLUSIONS
GlycA was associated with BMI and fitness among in US adolescents. These findings suggest that there are independent effects for BMI and fitness group with both GlycA and LP-IR. Future studies should validate the role of GlycA and LP-IR to evaluate the effects of interventions to modify obesity and fitness to improve systemic inflammation and insulin resistance.
背景
GlycA是一种新型的全身炎症血清标志物。目前尚无关于儿科人群中GlycA的信息，包括其在性别上的差异、与体重指数（BMI）或健康状况的关联。脂蛋白胰岛素抵抗指数（LP-IR）是一种胰岛素抵抗的血清指标，与青少年BMI组的变化有关，但其与健康状况的关系尚不清楚。本研究调查了美国青少年中健康状况和BMI与GlycA和LP-IR之间的独立关联。
方法
参与者为来自健康研究的1664名美国青少年，他们拥有完整的六年级和八年级BMI、健康状况及血液数据。通过核磁共振波谱法测量GlycA和LP-IR。创建了三个BMI组和三个健康状况组。采用线性混合模型研究GlycA、LP-IR、健康状况和BMI之间的关联。
结果
LP-IR在六年级到八年级期间有所下降。GlycA在女孩中升高，而在男孩中下降。在八年级时，女孩的GlycA中位数比男孩高27（7.6%）μmol·l⁻¹（381对354）。肥胖女孩六年级时的GlycA中位数比健康体重女孩高9%。总体而言，有强有力的证据（P<0.001）表明BMI较高的组中GlycA更高。在六年级和八年级评估时，健康状况与GlycA（r=-0.37和-0.35）及LP-IR（r=-0.34和-0.18）呈负相关。随着BMI类别增加和健康状况类别降低，GlycA和LP-IR水平升高。在低BMI/高健康状况组中发现GlycA最低。
结论
在美国青少年中，GlycA与BMI和健康状况相关。这些发现表明BMI和健康状况组对GlycA和LP-IR均有独立影响。未来的研究应验证GlycA和LP-IR在评估改变肥胖和健康状况以改善全身炎症和胰岛素抵抗的干预措施效果方面的作用。
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