用于牙周病和全身性疾病的唾液标志物
Salivary Markers for Periodontal and General Diseases.
作者信息
Podzimek Stepan, Vondrackova Lucie, Duskova Jana, Janatova Tatjana, Broukal Zdenek
机构信息
School of Dental Medicine, First Faculty of Medicine and General University Hospital, Charles University, Karlovo Namesti 32 and Katerinska 32, 121 11 Prague, Czech Republic.
出版信息
Dis Markers. 2016;2016:9179632. doi: 10.1155/2016/9179632. Epub 2016 Apr 6.
Abstract
The determination of biomarkers in saliva is becoming an important part of laboratory diagnostics and the prediction of not only periodontal, but also other tissue and organ diseases. Biomarkers in saliva (e.g., enzymes, protein markers, or oxidative stress markers) can be used for activity determination and for periodontal disease prognosis. Saliva also contains many markers which can predict the risk of certain diseases (e.g., diabetes mellitus, cardiovascular, oncology, endocrinology, and psychiatric diseases). The study of salivary components proteomics clearly shows the relationship of periodontal diseases and diseases of distant systems, organs, or tissues.
摘要
唾液中生物标志物的测定正成为实验室诊断的重要组成部分，不仅可用于牙周疾病的预测，还可用于其他组织和器官疾病的预测。唾液中的生物标志物（如酶、蛋白质标志物或氧化应激标志物）可用于活性测定和牙周疾病的预后评估。唾液中还含有许多可预测某些疾病（如糖尿病、心血管疾病、肿瘤疾病、内分泌疾病和精神疾病）风险的标志物。对唾液成分蛋白质组学的研究清楚地表明了牙周疾病与远处系统、器官或组织疾病之间的关系。
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