SET8的一个功能性单核苷酸多态性对乳腺癌具有预后价值。
A functional single nucleotide polymorphism of SET8 is prognostic for breast cancer.
作者信息
Liu Ben, Zhang Xining, Song Fengju, Liu Qun, Dai Hongji, Zheng Hong, Cui Ping, Zhang Lina, Zhang Wei, Chen Kexin
机构信息
Department of Epidemiology and Biostatistics, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
Department of Neurosurgery, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
出版信息
Oncotarget. 2016 Jun 7;7(23):34277-87. doi: 10.18632/oncotarget.9099.
A single-nucleotide polymorphism (SNP) locus rs16917496 (T > C) within the 3'-untranslated region (3'-UTR) of SET8 was associated with susceptibility in several malignancies including breast cancer. To further elucidate the prognostic relevance of this SNP in breast cancer, we conducted a clinical study as well as SET8 expression analysis in a cohort of 1,190 breast cancer patients. We demonstrated the expression levels of SET8 in TT genotype were higher than in CC genotypes, and high levels of SET8 were associated with poor survival. SET8 expression was significantly higher in breast tumor tissue than in paired adjacent normal tissue. In addition, survival analysis in 315 patients showed SNP rs16917496 was an independent prognostic factor of breast cancer outcome with TT genotype associated with poor survival compared with CC/CT genotypes. Thus, this SNP may serve as a genetic prognostic factor and a treatment target for breast cancer. Future studies are warranted.
SET8基因3'-非翻译区（3'-UTR）内的单核苷酸多态性（SNP）位点rs16917496（T>C）与包括乳腺癌在内的多种恶性肿瘤的易感性相关。为了进一步阐明该SNP在乳腺癌中的预后相关性，我们对1190例乳腺癌患者进行了临床研究及SET8表达分析。我们发现，TT基因型中SET8的表达水平高于CC基因型，且SET8高表达与较差的生存率相关。SET8在乳腺肿瘤组织中的表达明显高于配对的相邻正常组织。此外，对315例患者的生存分析表明，SNP rs16917496是乳腺癌预后的独立预测因素，与CC/CT基因型相比，TT基因型与较差的生存率相关。因此，该SNP可能作为乳腺癌的遗传预后因素和治疗靶点。未来有必要开展进一步研究。
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