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一例复发性恶性蝾螈瘤经放射治疗成功治愈。

A case of recurrent malignant triton tumor successfully treated with radiotherapy.

作者信息

Yasuda Makoto, Muto Yoko, Kuremoto Toshihiro, Murakami Kentaro, Onisihi Toshinori, Koida Atsuhide, Inui Takaaki, Hisa Yasuo

机构信息

Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.

Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.

出版信息

Auris Nasus Larynx. 2016 Dec;43(6):710-4. doi: 10.1016/j.anl.2016.04.003. Epub 2016 Apr 15.

Abstract

A 15-year-old female was previously admitted to another hospital because of painless swelling of the lateral right nasal ala for 2 months. Magnetic resonance imaging revealed an expansive enhancing lesion in close proximity to the anterior surface of the right maxillary sinus and lateral wall of the right nasal cavity. Tumor extirpation was performed via the supragingival transantral approach under general anesthesia. Histopathological study revealed a malignant triton tumor (MTT) arising from the nasal vestibule. The patient was referred to our department for consultation regarding additional treatment. Because the surgical margin was positive and MTT has high malignant potential, we recommended expansion re-surgical treatment following immediate free-flap reconstruction and postoperative radiotherapy, but family consent was not obtained. Tumor regrowth was noted 1 month after her first visit to our department. The patient and her family accepted radiotherapy instead of surgical treatment. Complete remission was achieved by radiotherapy alone. No local recurrence or distant metastasis was observed for 30 months after radiotherapy. The conventional mode of treatment for MTT is radical excision followed by high-dose radiotherapy. However, this case is remarkable because our patient experienced complete remission by simple radiotherapy.

摘要

一名15岁女性因右侧鼻翼外侧无痛性肿胀2个月,此前入住另一家医院。磁共振成像显示,在右上颌窦前表面和右鼻腔外侧壁附近有一个呈膨胀性强化的病变。在全身麻醉下,通过龈上经窦入路进行了肿瘤切除。组织病理学研究显示,肿瘤起源于鼻前庭,为恶性蝾螈瘤(MTT)。患者被转诊至我科咨询进一步治疗方案。由于手术切缘阳性且MTT具有较高的恶性潜能,我们建议在即刻游离皮瓣重建和术后放疗后进行扩大再次手术治疗,但未获得家属同意。患者首次就诊于我科1个月后,发现肿瘤复发。患者及其家属接受了放疗而非手术治疗。单纯放疗即实现了完全缓解。放疗后30个月未观察到局部复发或远处转移。MTT的传统治疗方式是根治性切除后进行大剂量放疗。然而,该病例值得注意,因为我们的患者通过单纯放疗实现了完全缓解。

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