a Department of Biochemistry and Biotechnology, Faculty of Science , Annamalai University , Annamalai Nagar , Tamil Nadu , India.
Pharm Biol. 2016 Nov;54(11):2521-2527. doi: 10.3109/13880209.2016.1168852. Epub 2016 May 9.
Myrtenal is monoterpene a constituent of essential oils found mainly in herbs such as mint, pepper, cumin, etc. It exerts admirable pharmacological activities against many diseases including diabetes. Hyperlipidaemia is a secondary complication of diabetes and also a major risk factor for cardiovascular diseases.
The present study investigated the possible antihyperlipidaemic efficacy of myrtenal on plasma glucose, pancreatic insulin, plasma and tissue lipid levels in streptozotocin (STZ) induced diabetic rats.
Diabetes was induced in male Wistar rats by a single intraperitoneal injection of STZ (40 mg/kg b.w.). Myrtenal (80 mg/kg) was administered orally to diabetic rats for a period of 28 d. Plasma glucose, pancreatic insulin, TC, TGs, FFAs, PLs, LDL-C, HDL-C, VLDL, atherogenic index, (HMG-CoA) reductase, LPL, LCAT and liver histology were analyzed.
Diabetic rats showed significantly (p < 0.05) increased plasma glucose (273.18 mg/dL), total cholesterol (142 mg/dL), triglycerides (126 mg/dL), free fatty acids (118 mg/dL), phospholipids (153 mg/dL), low-density lipoprotein (88.07 mg/dL), very low-density lipoprotein (25.2 mg/dL), atherogenic index, whereas a decrease in the levels of pancreatic insulin (97.48 ng/mg) and high-density lipoprotein (29.12 mg/dL). In addition, the activity of 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA) reductase (0.94 HMG-CoA ratio/(mevalonate) increased significantly in contrast to the activities of lipoprotein lipase (4.87 μmoles of glycerol liberated/h/L) and lecithin cholesterol acyltransferase (54.61 μmoles of cholesterol esterified/h/L) in diabetic rats. Treatment with myrtenal significantly (p < 0.05) improved the levels of plasma glucose, pancreatic insulin and lipid profiles. Moreover, the histopathological analysis of liver was also in agreement with the biochemical findings.
The present study indicates that myrtenal possess antihyperglycaemic and antihyperlipidemic properties, and could potentially be a useful phytochemical in treating diabetes.
迷迭香醇是单萜烯的一种组成部分，存在于薄荷、胡椒、孜然等草药的精油中。它对许多疾病表现出极好的药理活性，包括糖尿病。高脂血症是糖尿病的继发并发症，也是心血管疾病的主要危险因素。
本研究旨在研究迷迭香醇对链脲佐菌素（STZ）诱导的糖尿病大鼠血糖、胰腺胰岛素、血浆和组织脂质水平的可能抗高脂血症作用。
雄性 Wistar 大鼠通过单次腹腔注射 STZ（40mg/kg b.w.）诱导糖尿病。迷迭香醇（80mg/kg）灌胃给药 28 天。分析血浆葡萄糖、胰腺胰岛素、总胆固醇（TC）、甘油三酯（TGs）、游离脂肪酸（FFAs）、磷脂（PLs）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、极低密度脂蛋白（VLDL）、动脉粥样硬化指数、（HMG-CoA）还原酶、脂蛋白脂肪酶（LPL）、卵磷脂胆固醇酰基转移酶（LCAT）和肝组织学。
糖尿病大鼠的血浆葡萄糖（273.18mg/dL）、总胆固醇（142mg/dL）、甘油三酯（126mg/dL）、游离脂肪酸（118mg/dL）、磷脂（153mg/dL）、低密度脂蛋白（88.07mg/dL）、极低密度脂蛋白（25.2mg/dL）、动脉粥样硬化指数显著升高（p<0.05），而胰腺胰岛素（97.48ng/mg）和高密度脂蛋白（29.12mg/dL）水平降低。此外，糖尿病大鼠 3-羟-3-甲基戊二酰辅酶 A（HMG-CoA）还原酶（0.94 HMG-CoA 比/（甲羟戊酸）的活性显著增加，而脂蛋白脂肪酶（4.87μmol 甘油释放/h/L）和卵磷脂胆固醇酰基转移酶（54.61μmol 胆固醇酯化/h/L）的活性降低。用迷迭香醇治疗可显著改善血糖、胰腺胰岛素和血脂水平（p<0.05）。此外，肝组织学分析也与生化结果一致。
本研究表明，迷迭香醇具有降血糖和降血脂作用，可能是治疗糖尿病的有用植物化学物质。
Zotero 插件