Kumagai Junichiro, Kanda Tatsuo, Yasui Shin, Haga Yuki, Sasaki Reina, Nakamura Masato, Wu Shuang, Nakamoto Shingo, Arai Makoto, Iino Yotaro, Yokosuka Osamu
Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba, 220-8677, Japan.
Clin J Gastroenterol. 2016 Jun;9(3):156-9. doi: 10.1007/s12328-016-0648-5. Epub 2016 May 12.
We describe a case of autoimmune hepatitis (AIH) that may have occurred following drug-induced liver injury with camostat mesilate and/or benzbromarone in an elderly patient. The patient's liver biopsy showed chronic active hepatitis and autoimmune hepatitis. Stopping the use of these drugs did not lead to complete remission, but the use of a low dose of corticosteroids completely cured his liver dysfunction. In the present case, liver dysfunction was caused by an autoimmune mechanism. Special attention should be paid to idiopathic AIH and drug-induced AIH in elderly patients.
我们描述了一例自身免疫性肝炎(AIH)病例,该病例可能是在一名老年患者使用甲磺酸加贝酯和/或苯溴马隆导致药物性肝损伤后发生的。患者的肝活检显示为慢性活动性肝炎和自身免疫性肝炎。停用这些药物并未导致完全缓解,但使用低剂量的皮质类固醇完全治愈了他的肝功能障碍。在本病例中,肝功能障碍是由自身免疫机制引起的。老年患者应特别注意特发性AIH和药物性AIH。