载脂蛋白A5和载脂蛋白A1基因多态性与墨西哥儿童的甘油三酯水平相关。
APOA5 and APOA1 polymorphisms are associated with triglyceride levels in Mexican children.
作者信息
Suárez-Sánchez F, Klunder-Klunder M, Valladares-Salgado A, Gómez-Zamudio J, Peralta-Romero J, Meyre D, Burguete-García A, Cruz M
机构信息
Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional "Siglo XXI", Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Departamento de Investigación en Salud Comunitaria, Hospital Infantil de México Federico Gómez, Secretaria de Salud, Mexico City, Mexico.
出版信息
Pediatr Obes. 2017 Aug;12(4):330-336. doi: 10.1111/ijpo.12147. Epub 2016 May 12.
BACKGROUND
Dyslipidemia is an important risk factor for the development of several diseases. The genetic component of hypertriglyceridemia has been studied in adults, but little is known in children.
OBJECTIVE
The objective is to evaluate the association of two variants in APOA5 (rs662799) and APOA1 (rs5072) with triglyceride (TG) levels in Mexican children.
METHODS
Anthropometric parameters were measured in 1559 Mexican children 5-14 years of age. DNA was isolated from blood samples. Lipid profiles and glucose concentrations were determined from serum and genotyping of rs662799, and rs5072 was performed using TaqMan® technology. Additive and dominant models adjusted for age, gender and body mass index were used to evaluate the association of these single nucleotide polymorphisms with TG levels.
RESULTS
Children with high TG levels were found to have a higher body mass index and waist circumference as well as a worse lipids profile and glucose levels (p < 0.001). Additive and dominant models demonstrated a significant association between the rs662799 and rs5072 with TG. The dominant model showed the strongest significant association (OR = 1.81; 95% CI 1.46-2.24; p = 5.40 × 10 for rs662799 and OR = 1.54; 95% CI 1.05-2.25; p = 2.60 × 10 for rs5072).
CONCLUSION
The minor alleles of rs662799 (APOA5) and rs5072 (APOA1) modulate TG levels in Mexican children.
背景
血脂异常是多种疾病发生的重要危险因素。高甘油三酯血症的遗传成分在成人中已有研究，但在儿童中知之甚少。
目的
评估载脂蛋白A5（APOA5）基因的两个变异位点（rs662799）和载脂蛋白A1（APOA1）基因的两个变异位点（rs5072）与墨西哥儿童甘油三酯（TG）水平的关联。
方法
对1559名5至14岁的墨西哥儿童进行人体测量参数测定。从血样中提取DNA。采用TaqMan®技术测定血清中的血脂谱、血糖浓度以及rs662799和rs5072的基因分型。使用调整了年龄、性别和体重指数的加性模型和显性模型来评估这些单核苷酸多态性与TG水平的关联。
结果
发现高TG水平的儿童体重指数和腰围更高，血脂谱和血糖水平更差（p < 0.001）。加性模型和显性模型均显示rs662799和rs5072与TG之间存在显著关联。显性模型显示的关联最为显著（rs662799的OR = 1.81；95% CI 1.46 - 2.24；p = 5.40×10，rs5072的OR = 1.54；95% CI 1.05 - 2.25；p = 2.60×10）。
结论
rs662799（APOA5）和rs5072（APOA1）的次要等位基因可调节墨西哥儿童的TG水平。
Zotero 插件