概述改善药物生物利用度的胃滞留型药物传递系统。

Overview on gastroretentive drug delivery systems for improving drug bioavailability.

机构信息

Fernando Pessoa Energy, Environment and Health Research Unit/Biomedical Research Center (FP-ENAS/CEBIMED), Faculty of Health Sciences, Fernando Pessoa University, Rua Carlos da Maia, 296 P-4200-150 Porto, Portugal.

出版信息

Int J Pharm. 2016 Aug 20;510(1):144-58. doi: 10.1016/j.ijpharm.2016.05.016. Epub 2016 May 9.

DOI:10.1016/j.ijpharm.2016.05.016

PMID:27173823

Abstract

In recent decades, many efforts have been made in order to improve drug bioavailability after oral administration. Gastroretentive drug delivery systems are a good example; they emerged to enhance the bioavailability and effectiveness of drugs with a narrow absorption window in the upper gastrointestinal tract and/or to promote local activity in the stomach and duodenum. Several strategies are used to increase the gastric residence time, namely bioadhesive or mucoadhesive systems, expandable systems, high-density systems, floating systems, superporous hydrogels and magnetic systems. The present review highlights some of the drugs that can benefit from gastroretentive strategies, such as the factors that influence gastric retention time and the mechanism of action of gastroretentive systems, as well as their classification into single and multiple unit systems.

摘要

近几十年来，人们做出了许多努力以提高口服药物的生物利用度。胃滞留型药物传递系统就是一个很好的例子；它的出现旨在提高在上消化道吸收窗口较窄的药物的生物利用度和疗效，以及促进胃和十二指肠的局部活性。有几种策略可用于增加胃滞留时间，即生物黏附或黏膜黏附系统、可膨胀系统、高密度系统、漂浮系统、超多孔水凝胶和磁体系统。本综述强调了一些可受益于胃滞留策略的药物，例如影响胃滞留时间的因素和胃滞留型药物传递系统的作用机制，以及它们分为单单位和多单位系统的分类。