在链脲佐菌素诱导的糖尿病大鼠中给予黑种草籽（Nigella sativa）期间肾脏血流动力学和功能的恢复

Restoration of renal hemodynamics and functions during black cumin (Nigella sativa) administration in streptozotocin-induced diabetic rats.

作者信息

Yusuksawad Mariem, Chaiyabutr Narongsak

机构信息

Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Department of Physiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.

出版信息

J Exp Pharmacol. 2011 Dec 22;4:1-7. doi: 10.2147/JEP.S26054. eCollection 2012.

DOI:10.2147/JEP.S26054

PMID:27186112

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4863313/

Abstract

BACKGROUND

Black cumin (Nigella sativa) is an ancient herbal medicine recommended by the World Health Organization. The antioxidant and antihyperglycemic effects of black cumin are well established. Amelioration of renal dysfunction in nephrotoxic rats with black cumin treatment has also been noted. However, the effect of black cumin treatment on renal dysfunction in diabetes mellitus has not been clarified. In this study, the effect of black cumin oil (BC) on changes in renal dysfunction and renal hemodynamics in streptozotocin-induced diabetic rats was evaluated.

METHODS

The experiments were performed in male Sprague Dawley rats, divided into four groups (seven in each group): (1) normal rats given tap water (CON); (2) normal rats administered with BC (CON-BC); (3) diabetic rats given tap water only (STZ); and (4) diabetic rats administered with BC (STZ-BC). Diabetes mellitus was induced in the rats by an injection of streptozotocin. BC was given orally at the dose of 1000 mg/kg body weight to the rat in either CON-BC or STZ-BC every day for 8 weeks. Renal hemodynamics and functions in each rat were studied.

RESULTS

Renal hemodynamic changes in STZ-BC rats appeared to increase in terms of glomerular filtration rate, effective renal plasma flow, and effective renal blood flow, while renal vascular resistance and filtration fraction were decreased in comparison with diabetic rats given tap water only (STZ). An improvement of renal tubular dysfunction in STZ-BC rats was indicated by the decreases in fractional excretion of water and Mg(++).

CONCLUSION

An administration of BC can restore changes in renal hemodynamics and renal dysfunction in streptozotocin-induced diabetic rats.

摘要

背景

黑种草（Nigella sativa）是一种古老的草药，被世界卫生组织推荐。黑种草的抗氧化和降血糖作用已得到充分证实。用黑种草治疗肾毒性大鼠可改善其肾功能障碍，这一点也已被注意到。然而，黑种草治疗对糖尿病肾功能障碍的影响尚未阐明。在本研究中，评估了黑种草油（BC）对链脲佐菌素诱导的糖尿病大鼠肾功能障碍和肾血流动力学变化的影响。

方法

实验在雄性Sprague Dawley大鼠中进行，分为四组（每组七只）：（1）给予自来水的正常大鼠（CON）；（2）给予BC的正常大鼠（CON-BC）；（3）仅给予自来水的糖尿病大鼠（STZ）；（4）给予BC的糖尿病大鼠（STZ-BC）。通过注射链脲佐菌素诱导大鼠患糖尿病。CON-BC组或STZ-BC组的大鼠每天口服剂量为1000 mg/kg体重的BC，持续8周。研究了每只大鼠的肾血流动力学和功能。