SOX2在胃癌中的矛盾作用。
Paradoxical role of SOX2 in gastric cancer.
作者信息
Carrasco-Garcia Estefania, Santos Juliana C, Garcia Idoia, Brianti Mitsue, García-Puga Mikel, Pedrazzoli José, Matheu Ander, Ribeiro Marcelo L
机构信息
Neurooncology group, Biodonostia Health Research Institute Paseo Dr. Beguiristain s/n, San Sebastian 20014, Spain.
Unidade Integrada de Farmacologia e Gastroenterologia, Universidade São Francisco Bragança Paulista, SP, Brazil.
出版信息
Am J Cancer Res. 2016 Mar 15;6(4):701-13. eCollection 2016.
Sox2 is a critical regulator of embryogenesis and necessary for cellular reprogramming. It also plays an important role in tissue homeostasis and regeneration, maintaining the population of undifferentiated adult stem cells. Like various developmental and stem cell genes, SOX2 is aberrantly expressed and amplified in several human cancers. Moreover, functional studies have shown that it regulates many biological processes including cell proliferation, apoptosis, self-renewal and invasion. While it is oncogenic in most cancers, SOX2 activity is controversial in gastric cancer, where it might behave as a tumor suppressor in some situations. In this review, we discuss its role in cancer biology, with particular attention to what is known about the involvement of SOX2 in gastric cancer biology.
Sox2是胚胎发育的关键调节因子，也是细胞重编程所必需的。它在组织稳态和再生中也起着重要作用，维持未分化成体干细胞群体。与各种发育和干细胞基因一样，SOX2在几种人类癌症中异常表达并扩增。此外，功能研究表明它调节许多生物学过程，包括细胞增殖、凋亡、自我更新和侵袭。虽然它在大多数癌症中具有致癌性，但SOX2的活性在胃癌中存在争议，在某些情况下它可能表现为肿瘤抑制因子。在这篇综述中，我们讨论了它在癌症生物学中的作用，特别关注了SOX2在胃癌生物学中的参与情况。
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