Pitter Frederik T, Jørgensen Christoffer C, Lindberg-Larsen Martin, Kehlet Henrik
From the *Section for Surgical Pathophysiology 4074, Rigshospitalet, Copenhagen University, Copenhagen, Denmark; †The Lundbeck Foundation Centre for Fast-track Hip and Knee Replacement, Copenhagen, Denmark; and ‡Department of Orthopedic Surgery, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark.
Anesth Analg. 2016 Jun;122(6):1807-15. doi: 10.1213/ANE.0000000000001190.
Elderly patients are at risk of increased length of hospital stay (LOS), postoperative complications, readmission, and discharge to destinations other than home after elective total hip arthroplasty (THA) and total knee arthroplasty (TKA). Recent studies have found that enhanced recovery protocols or fast-track surgery can be safe for elderly patients undergoing these procedures and may result in reduced LOS. However, detailed studies on preoperative comorbidity and differentiation between medical and surgical postoperative morbidity in elderly patients are scarce. The aim of this study was to provide detailed information on postoperative morbidity resulting in LOS >4 days or readmissions <90 days after fast-track THA and TKA in patients ≥85 years.
This is a descriptive, observational study in consecutive unselected patients ≥85 years undergoing fast-track THA/TKA. The primary outcome was the causes of postoperative morbidity leading to an LOS of >4 days. Secondary outcomes were 90-day surgically related readmissions, discharge destination, 90-day mortality, and role of disposing factors for LOS >4 days and 90-day readmissions. Data on preoperative characteristics were prospectively gathered using patient-reported questionnaires. Data on all admissions were collected using the Danish National Health Registry, ensuring complete follow-up. Any cases of LOS >4 days or readmissions were investigated through review of discharge forms or medical records. Backward stepwise logistic regression was used for analysis of association between disposing factors and LOS >4 days and 90-day readmission.
Of 13,775 procedures, 549 were performed in 522 patients ≥85 years. Median age was 87 years (interquartile range, 85-88) and median LOS of 3 days (interquartile range, 2-5). In 27.3% procedures, LOS was >4 days, with 82.7% due to medical causes, most often related to anemia requiring blood transfusion and mobilization issues. Use of walking aids was associated with LOS >4 days (odds ratio [OR], 1.99; 95% confidence interval [CI], 1.26-3.15; P = 0.003), whereas preoperative anemia showed borderline significance (OR, 1.52; 95% CI, 0.99-2.32; P = 0.057). Thirty-eight patients (6.9%) were not discharged directly home, of which 68.4% had LOS >4 days. Readmission rates were 14.2% and 17.9% within 30 and 90 days, respectively, and 75.5% of readmissions within 90 days were medical, mainly due to falls and suspected but disproved venous thromboembolic events. Preoperative anemia was associated with increased (OR, 1.81; 95% CI, 1.13-2.91; P = 0.014) and living alone with decreased (OR, 0.50; 95% CI, 0.31-0.80; P = 0.004) risk of 90-day readmissions. Ninety-day mortality was 2.0%, with 1.0% occurring during primary admission.
Fast-track THA and TKA with an LOS of median 3 days and discharge to home are feasible in most patients ≥85 years. However, further attention to pre- and postoperative anemia and the pathogenesis of medical complications is needed to improve postoperative outcomes and reduce readmissions.
老年患者在接受择期全髋关节置换术(THA)和全膝关节置换术(TKA)后,有住院时间(LOS)延长、术后并发症、再入院以及出院后未回家而是前往其他目的地的风险。最近的研究发现,强化康复方案或快速康复手术对于接受这些手术的老年患者可能是安全的,并且可能会缩短住院时间。然而,关于老年患者术前合并症以及内科和外科术后发病率差异的详细研究较少。本研究的目的是提供有关≥85岁患者在快速康复THA和TKA术后导致住院时间>4天或90天内再入院的术后发病率的详细信息。
这是一项对连续入选的≥85岁接受快速康复THA/TKA的患者进行的描述性观察研究。主要结局是导致住院时间>4天的术后发病原因。次要结局是90天内与手术相关的再入院情况、出院目的地、90天死亡率以及导致住院时间>4天和90天再入院的处置因素的作用。术前特征数据通过患者报告问卷前瞻性收集。所有入院数据使用丹麦国家健康登记处收集,以确保完整随访。任何住院时间>4天或再入院的病例通过审查出院表格或病历进行调查。采用向后逐步逻辑回归分析处置因素与住院时间>4天和90天再入院之间的关联。
在13775例手术中,522例≥85岁患者进行了549例手术。中位年龄为87岁(四分位间距,85 - 88岁),中位住院时间为3天(四分位间距,2 - 5天)。在27.3%的手术中,住院时间>4天,其中82.7%是由于内科原因,最常见的是与需要输血的贫血和活动问题有关。使用助行器与住院时间>4天相关(比值比[OR],1.99;95%置信区间[CI],1.26 - 3.15;P = 0.003),而术前贫血显示出临界显著性(OR,1.52;95% CI,0.99 - 2.32;P = 0.057)。38例患者(6.9%)未直接出院回家,其中68.4%的患者住院时间>4天。30天和90天内的再入院率分别为14.2%和17.9%,90天内75.5%的再入院是内科原因,主要是由于跌倒以及疑似但未证实的静脉血栓栓塞事件。术前贫血与90天再入院风险增加相关(OR,1.81;95% CI,1.13 - 2.91;P = 0.014),而独居与90天再入院风险降低相关(OR,0.50;95% CI,0.31 - 0.80;P = 0.004)。90天死亡率为2.0%,其中1.0%发生在初次住院期间。
对于大多数≥85岁的患者,中位住院时间为3天且出院回家的快速康复THA和TKA是可行的。然而,需要进一步关注术前和术后贫血以及内科并发症的发病机制,以改善术后结局并减少再入院情况。