被动吸烟与结直肠癌风险：观察性研究的荟萃分析
Passive Smoking and Risk of Colorectal Cancer: A Meta-analysis of Observational Studies.
作者信息
Yang Chen, Wang Xin, Huang Chang-Hao, Yuan Wei-Jie, Chen Zi-Hua
机构信息
Xiangya Hospital, Central South University, Changsha, Hunan Province, China
Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
出版信息
Asia Pac J Public Health. 2016 Jul;28(5):394-403. doi: 10.1177/1010539516650724. Epub 2016 May 23.
We conducted this meta-analysis to explore the association between passive smoking and the risk of colorectal cancer. A literature search of online databases, including MEDLINE, EMBASE, the Cochrane Library, and Web of Science was performed up to June 30, 2015. A fixed-effects meta-analysis using Stata 12.0 was carried out to estimate the relative risks (RRs) and 95% confidence intervals (CIs) for the associations. Eleven articles, including 6 case-control studies and 6 cohort studies, were included in our analysis according to inclusion and exclusion criteria. The pooled RR of all studies showed a statistically significant association between passive smoking and colorectal cancer (RR = 1.14; 95% CI = 1.05-1.24). Results of subgroup analysis showed a positive association between passive smoking and rectal cancer ((RR = 1.33; 95% CI = 1.15-1.53) and that male passive smokers were at greater risks of colorectal cancer (RR = 1.73; 95% CI = 1.37-2.19) than females. Results suggested that passive smoking is associated with an increased risk of colorectal cancer.
我们进行了这项荟萃分析，以探讨被动吸烟与结直肠癌风险之间的关联。截至2015年6月30日，我们对包括MEDLINE、EMBASE、Cochrane图书馆和科学网在内的在线数据库进行了文献检索。使用Stata 12.0进行固定效应荟萃分析，以估计这些关联的相对风险（RRs）和95%置信区间（CIs）。根据纳入和排除标准，我们的分析纳入了11篇文章，包括6项病例对照研究和6项队列研究。所有研究的合并RR显示，被动吸烟与结直肠癌之间存在统计学上的显著关联（RR = 1.14；95% CI = 1.05 - 1.24）。亚组分析结果显示，被动吸烟与直肠癌之间存在正相关（RR = 1.33；95% CI = 1.15 - 1.53），并且男性被动吸烟者患结直肠癌的风险（RR = 1.73；95% CI = 1.37 - 2.19）高于女性。结果表明，被动吸烟与结直肠癌风险增加有关。
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