角膜缘干细胞缺乏症的眼表重建
Ocular surface reconstruction in limbal stem cell deficiency.
作者信息
Gheorghe Alina, Pop Monica, Mrini Fildis, Barac Ramona, Vargau Iulia
出版信息
Rom J Ophthalmol. 2016 Jan-Mar;60(1):2-5.
Abstract
The purpose of our review was to familiarize the readers with the new concepts in ocular surface diseases and reconstruction. Limbal stem cell deficiency is characterized by the progressive invasion of conjunctival epithelial cells onto the cornea, superficial vascularisation, destruction of the corneal basement membrane, and chronic inflammatory cell infiltration. Depending on the severity of the disease and the time passed from the primary injury amniotic membrane transplantation, keratolimbal allograft and autograft are the available treatments hoping that, in the nearest future, stem cell transplantation and tissue engineering will become the usual therapeutic choices.
摘要
我们此次综述的目的是让读者熟悉眼表疾病及重建方面的新概念。角膜缘干细胞缺乏的特征为结膜上皮细胞逐渐侵入角膜、浅层血管化、角膜基底膜破坏以及慢性炎性细胞浸润。根据疾病的严重程度以及自初次损伤后经过的时间，羊膜移植、角膜缘同种异体移植和自体移植是现有的治疗方法，期望在不久的将来，干细胞移植和组织工程将成为常用的治疗选择。
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