一个与FRA16B（位于16q22.1的脆性位点）相关的连锁群。

A linkage group with FRA16B (the fragile site at 16q22.1).

作者信息

Mulley J C, Hyland V J, Fratini A, Bates L J, Gedeon A K, Sutherland G R

机构信息

Department of Histopathology, Adelaide Children's Hospital, Australia.

出版信息

Hum Genet. 1989 May;82(2):131-3. doi: 10.1007/BF00284044.

DOI:10.1007/BF00284044

Abstract

Polymorphic DNA markers located in bands 16q13, 16q21 and 16q22 were examined for recombination with FRA16B, the fragile site at 16q22.100. A tight linkage cluster D16S10-FRA16B-D16S4-HP was established. There were no recombinants (theta = 0.0, z = 8.3) between D16S10 and D16S4, which flank FRA16B. The markers D16S10 and D16S4 are in close proximity on the genetic map and delineate a small chromosomal segment, which contains the distamycin A-inducible fragile site.

摘要

对位于16q13、16q21和16q22条带中的多态性DNA标记进行检测，以确定其与位于16q22.100的脆性位点FRA16B是否发生重组。建立了一个紧密连锁群D16S10-FRA16B-D16S4-HP。位于FRA16B两侧的D16S10和D16S4之间没有重组体（θ = 0.0，z = 8.3）。标记D16S10和D16S4在遗传图谱上位置相近，划定了一个小的染色体区段，该区段包含放线菌素D诱导的脆性位点。

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