Kälin Martin, Mauti Laetitia, Pless Miklos
1 Medizinische Onkologie, Kantonsspital Winterthur.
Praxis (Bern 1994). 2016 May 25;105(11):643-8. doi: 10.1024/1661-8157/a002364.
Germ cell tumours represent a rare malignancy that affects mostly young men between 15 and 40 years of age. In approximately 50 % of the cases pure seminoma is found, 50 % non-seminomas are divided into hetrogenous subgroups. The initial therapeutic step usually is orchiectomy, further procedures are defined by histology, clinical staging and risk profile.Therpeutical options consist in active surveillance, radiotherapy or chemotherapy. Stage I shows a cure rate of almost 100 %but even in metastatic stages more then 80 % of all patients can be cured. However they must remain in a close longterm followup during which especially cardiovascular risk factors have to be monitored.
生殖细胞肿瘤是一种罕见的恶性肿瘤,主要影响15至40岁的年轻男性。大约50%的病例为纯精原细胞瘤,50%的非精原细胞瘤分为异质性亚组。初始治疗步骤通常是睾丸切除术,进一步的治疗程序由组织学、临床分期和风险特征决定。治疗选择包括主动监测、放疗或化疗。I期的治愈率几乎为100%,但即使在转移阶段,所有患者中超过80%也可以治愈。然而,他们必须接受长期密切随访,在此期间尤其要监测心血管危险因素。