5%他氟康唑溶液：一种治疗趾甲甲真菌病的新型局部用药

Tavaborole 5% Solution: A Novel Topical Treatment for Toenail Onychomycosis.

作者信息

Gupta G, Foley K A, Gupta A K

机构信息

Wayne State University, Detroit, MI, USA; Mediprobe Research Inc., London, ON, Canada.

Mediprobe Research Inc., London, ON, Canada.

出版信息

Skin Therapy Lett. 2015 Nov;20(6):6-9.

PMID:27224843

Abstract

Onychomycosis is a stubborn fungal infection of the nails that can be difficult to effectively manage. One of the challenges with topical therapies is penetrating the nail plate to reach the site of infection. As the first antifungal in a boron-containing class of drugs with a novel mechanism of action, tavaborole is able to penetrate the nail plate more effectively than ciclopirox and amorolfine lacquers. In Phase II/III clinical trials, tavaborole was shown to be safe and clinically effective. Tavaborole 5% solution was approved by the US FDA for the treatment of toenail onychomycosis in July 2014 and is an important addition to the topical treatment arsenal against this stubborn infection.

摘要

甲癣是一种顽固的指甲真菌感染，难以有效治疗。局部治疗的挑战之一是穿透甲板到达感染部位。作为具有新型作用机制的含硼类药物中的首个抗真菌药，他氟硼酸盐比环吡酮和阿莫罗芬搽剂能更有效地穿透甲板。在II/III期临床试验中，他氟硼酸盐被证明是安全且临床有效的。2014年7月，5%他氟硼酸盐溶液被美国食品药品监督管理局批准用于治疗趾甲甲癣，是针对这种顽固感染的局部治疗武器库中的一项重要补充。