单肾照射后成熟猪的肾病：与未成熟猪的比较。

Robbins M E, Campling D, Rezvani M, Golding S J, Hopewell J W

CRC Normal Tissue Radiobiology Research Group, Research Institute (University of Oxford), UK.

Int J Radiat Oncol Biol Phys. 1989 Jun;16(6):1519-28. doi: 10.1016/0360-3016(89)90957-7.

The right kidney of 11 mature 10-month-old Large White female pigs was irradiated with single doses of 9.8-14.0 Gy of 60Co gamma rays. Individual kidney glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were measured using 99mTc-DTPA and 131I-hippuran renography for periods up to 24 weeks after irradiation. Renal function was assessed either as a functional index, FI (FI = irradiated/unirradiated kidney function), or as the individual kidney GFR and ERPF. The radiation-induced changes after the irradiation of a single kidney (unilaterally irradiated--UI) of mature pigs were compared with those previously observed in 14-week-old immature pigs. Irradiation resulted in a dose-dependent reduction in the FI for both GFR and ERPF. However, these reductions were significantly less than those previously seen in immature pigs. Within 2 weeks of irradiation GFR increased in both the irradiated and the unirradiated kidneys in each animal, compared with unirradiated age-matched control kidneys. No marked changes in renal hemodynamics were seen in mature animals after a single dose of 9.8 Gy. This was in marked contrast to the pronounced reduction in the GFR and ERPF in the irradiated kidney previously observed in immature animals irradiated with an equivalent single dose of X rays. After higher doses, the irradiated kidney in mature pigs showed a dose-dependent reduction in GFR and ERPF. However, the extent of this reduction was significantly less than that seen in immature animals. There was no apparent difference in the response of the unirradiated kidneys in mature or immature pigs. The ED50 values, based on a probit fit to the data for the proportion of functional tests in which the irradiated kidney showed a greater than or equal to 50% reduction in GFR or ERPF, were higher in the mature animals; for example for ERPF the ED50 values were 11.76 +/- 0.28 Gy and 7.67 +/- 0.34 Gy for mature and immature animals, respectively. Thus, the UI kidney in mature pigs appears to be less radiosensitive than the UI kidney in immature animals.

对11头10月龄成熟大白母猪的右肾进行单次剂量为9.8 - 14.0 Gy的60Coγ射线照射。在照射后的24周内，使用99mTc - DTPA和131I - 马尿酸肾图测量个体肾脏的肾小球滤过率（GFR）和有效肾血浆流量（ERPF）。肾功能评估采用功能指数FI（FI = 照射后肾脏功能/未照射肾脏功能），或个体肾脏的GFR和ERPF。将成熟猪单肾照射（单侧照射 - UI）后的辐射诱导变化与之前在14周龄未成熟猪中观察到的变化进行比较。照射导致GFR和ERPF的FI呈剂量依赖性降低。然而，这些降低程度明显小于之前在未成熟猪中所见。与未照射的年龄匹配对照肾脏相比，照射后2周内，每只动物的照射肾脏和未照射肾脏的GFR均增加。单次剂量9.8 Gy照射后，成熟动物的肾脏血流动力学未见明显变化。这与之前用等效单次剂量X射线照射的未成熟动物中观察到的照射肾脏的GFR和ERPF明显降低形成鲜明对比。更高剂量照射后，成熟猪的照射肾脏GFR和ERPF呈剂量依赖性降低。然而，这种降低程度明显小于未成熟动物。成熟或未成熟猪未照射肾脏的反应无明显差异。基于对功能测试比例数据的概率拟合得出的ED50值，即照射肾脏GFR或ERPF降低大于或等于50%的功能测试比例，成熟动物的值更高；例如，对于ERPF，成熟动物和未成熟动物的ED50值分别为11.76±0.28 Gy和7.67±0.34 Gy。因此，成熟猪的UI肾脏似乎比未成熟动物的UI肾脏对辐射更不敏感。