老年西班牙裔人群中阿尔茨海默病和轻度认知障碍的血清蛋白谱。
Serum-based protein profiles of Alzheimer's disease and mild cognitive impairment in elderly Hispanics.
作者信息
Villarreal Alcibiades E, O'Bryant Sid E, Edwards Melissa, Grajales Shantal, Britton Gabrielle B
机构信息
Centro de Neurociencias y Unidad de Investigación Clínica, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Ciudad del Saber 219, Clayton, Apartado Postal 0843-01103, República de Panamá
Department of Biotechnology, Acharya Nagarjuna University, Guntur, India.
出版信息
Neurodegener Dis Manag. 2016 Jun;6(3):203-13. doi: 10.2217/nmt-2015-0009. Epub 2016 May 27.
AIM
To describe the biomarker profiles in elderly Panamanians diagnosed with Alzheimer's disease (AD), mild cognitive impairment (MCI) or no impairment using serum-based biomarkers.
METHODS
Twenty-four proteins were analyzed using an electrochemiluminescence-based multiplex biomarker assay platform. A biomarker profile was generated using random forest analyses.
RESULTS
Two proteins differed among groups: IL-18 and T-lymphocyte-secreted protein I-309. The AD profile was highly accurate and independent of age, gender, education and Apolipoprotein E ε4 status. AD and MCI profiles had substantial overlap among the top markers, suggesting common functions in AD and MCI but differences in their relative importance.
CONCLUSION
Our results underscore the potential influence of genetic and environmental differences within Hispanic populations on the proteomic profile of AD.
目的
使用基于血清的生物标志物来描述被诊断患有阿尔茨海默病（AD）、轻度认知障碍（MCI）或无认知障碍的巴拿马老年人的生物标志物谱。
方法
使用基于电化学发光的多重生物标志物检测平台分析24种蛋白质。使用随机森林分析生成生物标志物谱。
结果
两组之间有两种蛋白质存在差异：白细胞介素-18（IL-18）和T淋巴细胞分泌蛋白I-309。AD谱具有高度准确性，且独立于年龄、性别、教育程度和载脂蛋白Eε4状态。AD和MCI谱在顶级标志物之间有大量重叠，表明在AD和MCI中存在共同功能，但它们各自的相对重要性有所不同。
结论
我们的结果强调了西班牙裔人群中遗传和环境差异对AD蛋白质组学谱的潜在影响。
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