来自竹叶椒的肉桂酰酰胺及其合成类似物对小菜蛾（Plutella xylostella）的杀幼虫活性及构效关系

Larvicidal activity and structure activity relationship of cinnamoyl amides from Zanthoxylum armatum and their synthetic analogues against diamondback moth, Plutella xylostella.

作者信息

Kumar Vishal, Reddy S G Eswara, Bhardwaj Anuja, Dolma Shudh Kirti, Kumar Neeraj

机构信息

Natural Product Chemistry and Process Development Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur-176061, Himachal Pradesh, India.

Entomology Laboratory, CSIR-Institute of Himalayan Bioresource Technology, Palampur-176061, Himachal Pradesh, India.

出版信息

EXCLI J. 2016 Mar 18;15:229-37. doi: 10.17179/excli2016-166. eCollection 2016.

DOI:10.17179/excli2016-166

PMID:27231477

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4874319/

Abstract

Cinnamoyl amides isolated from Zanthoxylum armatum (Rutaceae) and their synthetic analogues were tested for their insecticidal activity against the second instar larvae of diamondback moth, Plutella xylostella (L.) (Lepidoptera: Yponomeutidae) to determine the promising structures with insecticidal activity. Most of the test compounds showed promising activity against larvae of P. xylostella. However, the activities of different compounds varied depending on the presence of different substituents at various positions of both the aromatic rings A and B. Among the tested compounds, 8, N-(3-bromo-4-methoxyphenethyl)cinnamamide showed best larvicidal activity with an LC50 = 62.13 mg/L followed by 6, N-(3׳-bromophenethyl)cinnamamide (LC50=128.49 mg/L) and 2 N-(4׳-methoxyphenylethyl)cinnamamide (LC50 = 225.65 mg/L).

摘要

对从竹叶花椒（芸香科）中分离得到的肉桂酰胺及其合成类似物进行了测试，以检测其对小菜蛾（鳞翅目：菜蛾科）二龄幼虫的杀虫活性，从而确定具有杀虫活性的潜在结构。大多数测试化合物对小菜蛾幼虫表现出有前景的活性。然而，不同化合物的活性因芳环A和B不同位置上不同取代基的存在而有所差异。在测试的化合物中，8，N-(3-溴-4-甲氧基苯乙基)肉桂酰胺表现出最佳的杀幼虫活性，LC50 = 62.13 mg/L，其次是6，N-(3'-溴苯乙基)肉桂酰胺（LC50 = 128.49 mg/L）和2 N-(4'-甲氧基苯乙基)肉桂酰胺（LC50 = 225.65 mg/L）。