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蠕虫与肠道菌群协同作用以改善肠道健康。

Helminths and Intestinal Flora Team Up to Improve Gut Health.

作者信息

Giacomin Paul, Agha Zainab, Loukas Alex

机构信息

Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia.

Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia.

出版信息

Trends Parasitol. 2016 Sep;32(9):664-666. doi: 10.1016/j.pt.2016.05.006. Epub 2016 May 24.

Abstract

Inflammatory bowel diseases (IBD) are associated with impaired intestinal barrier function, chronic inflammation, and microbial dysbiosis. In a recent publication in Science, Ramanan et al. used murine and human studies to demonstrate that infections with gastrointestinal helminths can protect against IBD by provoking immune responses that alter the balance of commensal and pathogenic bacteria in the intestine.

摘要

炎症性肠病(IBD)与肠道屏障功能受损、慢性炎症和微生物群落失调有关。在最近发表于《科学》杂志的一篇文章中,拉马南等人通过小鼠和人体研究表明,胃肠道蠕虫感染可引发免疫反应,改变肠道内共生菌和致病菌的平衡,从而预防IBD。

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