印度北部一家三级医疗转诊中心先天性白内障中的感染因子

Infectious agents in congenital cataract in a tertiary care referral center in North India.

作者信息

Singh Mini P, Ram Jagat, Kumar Archit, Khurana Jasmine, Marbaniang Merinda, Ratho Radha Kanta

机构信息

Department of Virology, Postgraduate Institute of Medical Education and Research, Chandigarh, India, 160 012.

Department of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India, 160 012.

出版信息

Diagn Microbiol Infect Dis. 2016 Aug;85(4):477-81. doi: 10.1016/j.diagmicrobio.2016.05.007. Epub 2016 May 12.

DOI:10.1016/j.diagmicrobio.2016.05.007

PMID:27236713

Abstract

Congenital cataract has the potential for inhibiting early visual development. Intrauterine infections with Rubella virus, Herpes simplex virus (HSV) and Toxoplasma gondii plays an important role in the development of congenital cataract. The study included 120 children under the age of 6 years presenting with congenital cataract and diagnosed using serology and polymerase chain reaction (PCR). The IgM positivity for rubella, HSV, T. gondii was found to be 5.8%, 1.6% and 8.3% respectively. The overall PCR positivity was found to be 40(33.3%), 25 (20.8%) and 39 (32.5%) for rubella, HSV and T. gondii with mean copy number of 1599 copies/μL; 1716 copies/μL and 1503 copies/μL respectively. Infective etiology significantly contributes to the causation of congenital cataract particularly for rubella virus which is a potentially eradicable disease. This study provides an epidemiological data for rubella, HSV and T. gondii in children with congenital cataract and highlights the need to introduce rubella vaccine in the National Immunization Programme of India.

摘要

先天性白内障有可能抑制早期视觉发育。风疹病毒、单纯疱疹病毒（HSV）和弓形虫的宫内感染在先天性白内障的发生发展中起重要作用。该研究纳入了120名6岁以下患有先天性白内障的儿童，并通过血清学和聚合酶链反应（PCR）进行诊断。发现风疹、HSV、弓形虫的IgM阳性率分别为5.8%、1.6%和8.3%。风疹、HSV和弓形虫的总体PCR阳性率分别为40例（33.3%）、25例（20.8%）和39例（32.5%），平均拷贝数分别为1599拷贝/μL、1716拷贝/μL和1503拷贝/μL。感染性病因对先天性白内障的病因有显著影响，尤其是风疹病毒，这是一种有可能根除的疾病。本研究提供了先天性白内障患儿中风疹、HSV和弓形虫的流行病学数据，并强调了在印度国家免疫规划中引入风疹疫苗的必要性。