电化学 C-H/N-H 官能团化在高度官能化（氮杂）吲哚合成中的应用。
Electrochemical C-H/N-H Functionalization for the Synthesis of Highly Functionalized (Aza)indoles.
机构信息
Collaborative Innovation Center of Chemistry for Energy Material, State Key Laboratory of Physical Chemistry of Solid Surfaces, Key Laboratory of Chemical Biology of Fujian Province and, Department of Chemistry, Xiamen University, Xiamen, 361005, P.R. China.
Fujian Institute of Research on Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, P.R. China.
出版信息
Angew Chem Int Ed Engl. 2016 Aug 1;55(32):9168-72. doi: 10.1002/anie.201602616. Epub 2016 May 30.
Indoles and azaindoles are among the most important heterocycles because of their prevalence in nature and their broad utility in pharmaceutical industry. Reported herein is an unprecedented noble-metal- and oxidant-free electrochemical method for the coupling of (hetero)arylamines with tethered alkynes to synthesize highly functionalized indoles, as well as the more challenging azaindoles.
吲哚和氮茚是最重要的杂环化合物之一，因为它们在自然界中普遍存在，并且在制药工业中有广泛的用途。本文报道了一种前所未有的、无贵金属和氧化剂的电化学方法，用于（杂）芳基胺与连接的炔烃的偶联，以合成高度官能化的吲哚，以及更具挑战性的氮茚。
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