使用BF3-Et2O通过区域选择性缩合反应从多羰基芳香化合物高效合成查耳酮。

Highly Efficient Synthesis of Chalcones from Poly Carbonyl Aromatic Compounds Using BF3-Et2O via a Regioselective Condensation Reaction.

作者信息

Julakanti Satyanarayana Reddy, Patel Manimala, Ponneri Venkateswarlu

机构信息

Natural Products Chemistry Division, CSIR Indian Institute of Chemical Technology.

出版信息

Chem Pharm Bull (Tokyo). 2016;64(6):570-6. doi: 10.1248/cpb.c15-00939.

DOI:10.1248/cpb.c15-00939

PMID:27250791

Abstract

A new, simple, highly efficient method for the synthesis of different types of carbonyl chalcones through a regioselective condensation reaction of appropriate 5-acetyl-2-hydroxybenzaldehyde with various substituted acetophenones and 4-hydroxyisothalaldehyde with various substituted aldehydes using BF3-Et2O as a reagent is described.

摘要

描述了一种新的、简单且高效的方法，该方法通过使用BF3-Et2O作为试剂，使合适的5-乙酰基-2-羟基苯甲醛与各种取代的苯乙酮进行区域选择性缩合反应，以及使4-羟基异硫代苯甲醛与各种取代的醛进行区域选择性缩合反应，来合成不同类型的羰基查耳酮。